Hyperammonemia Associated with Valproic Acid Concentrations

Table 2

Pharmacokinetic parameters in saliva after delayed-release and extended-release VPA intake.

Pharmacokinetic parameters	VPA DR	VPA ER
𝐶maxss (mg/L)	2.82	2.06
𝐶minss (mg/L)	1.25	1.02
𝑇maxss (hours)	2	10
AUCss0--12 (mg·h/L)	19.1	18.1
𝐶meanss (mg/L)	1.59	1.51
PTF	98.7	68.9

DR: delayed-release; ER: extended-release; PTF: peak-trough fluctuations; AUC_ss0--12: area under the curve from 0 to 12 hours; 𝐶max_ss: maximum concentration at steady state; 𝐶min_ss: minimum concentration at steady state; 𝑇max_ss: time to obtain 𝐶max_ss.