Independent Value of Cardiac Troponin T and Left Ventricular Global Longitudinal Strain in Predicting All-Cause Mortality among Stable Hemodialysis Patients with Preserved Left Ventricular Ejection Fraction

Table 5

Additional predictive values of cTnT × 100 and less negative GLS (≥−15%) for mortality using Cox regression models analysis and ROC curve analysis.

The additional value of cTnT × 100 and less negative GLS (≥−15%) in model prediction for mortality using Cox regression models analysis with analysis of deviance			The additional predictive value of cTnT × 100 and less negative GLS (≥−15%) based on ROC curve analysis with calculated AUCs
	Chi-square	𝑃		AUC	95% CI	𝑃^#	𝑃^##
Albumin + hypertension + GLS ≥ −15% versus albumin + hypertension + GLS ≥−15% + cTnT × 100	9.88	0.002*	Albumin + hypertension	0.68	(0.53–0.81)	—	—
Albumin + hypertension + cTnT × 100 versus albumin + hypertension + cTnT × 100 + GLS ≥ −15%	4.56	0.05*	Albumin + hypertension + GLS ≥ −15%	0.77	(0.65–0.88)	0.03*	—
			Albumin + hypertension + cTnT × 100	0.78	(0.6–0.89)	0.02*	—
			Albumin + hypertension + GLS ≥ −15% + cTnT × 100	0.85	(0.75–0.94)	<0.001*	—
Basic model versus basic model + GLS ≥ −15%	4.51	0.03*	Basic model	0.74	(0.62–0.86)	—	—
Basic model versus basic model + cTnT × 100	9.87	0.003*	Basic model + GLS ≥ −15%	0.81	(0.69–0.91)	—	0.04*
Basic model + GLS ≥ −15% versus  basic model + GLS ≥ −15% + cTnT × 100	6.90	0.009*	Basic model + cTnT × 100	0.82	(0.71–0.91)	—	0.03*
Basic model + cTnT × 100 versus  basic model + cTnT × 100 + GLS ≥ −15%	4.53	0.046*	Basic model + GLS ≥ −15% + cTnT × 100	0.89	(0.77–0.95)	—	0.001*
Basic model versus  basic model + GLS ≥ −15% + cTnT × 100	11.40	0.002*

First, we included background hypertension and plasma albumin concentration but excluded diabetes and coronary arterial disease based on final reduced model of Table 4 and studied the additional predictive values of cTnT × 100 and less negative GLS (≥−15%) to mortality. Then, we included diabetes and coronary arterial disease in addition to hypertension and serum albumin concentration to construct the basic model because they are commonly used for risk stratification in the hemodialysis population, and studied the additional predictive values of cTnT × 100 and less negative GLS (≥−15%) to mortality. ^∗𝑃<0.05; ^#comparing the AUC of indicated model with that of the model including background hypertension and plasma albumin concentration; ^##comparing the AUC of indicated model with that of the model including background coronary arterial disease, diabetes and hypertension, and plasma albumin concentration.
Abbreviations: AUC: area under curve; CI: confidence interval; cTnT: cardiac troponin T; GLS: global left ventricular peak systolic longitudinal strain.