Activity Exerted by a Testosterone Derivative on Myocardial Injury Using an Ischemia/Reperfusion Model
Figure 6
Effects induced by the testosterone and its derivative on LVP through androgen receptor. Intracoronary boluses (50 μL) of the testosterone and its derivative [0.001 to 100 nM] were administered and the corresponding effect on the LVP was determined. The dose-response curve (control) was repeated in the presence of flutamide (duration of preincubation with flutamide was by a 10 min equilibration period). The results showed that only the activity exerted of testosterone on LVP was significantly inhibited (). Each bar represents the mean ± SE of 9 experiments. LVP: left ventricular pressure.
