Activity Exerted by a Testosterone Derivative on Myocardial Injury Using an Ischemia/Reperfusion Model

Figure 8

Effects induced by the testosterone derivative on LVP through calcium channel activation. Intracoronary boluses (50 μL) of the testosterone derivative [0.001 to 100 nM] were administered and the corresponding effect on the LVP was determined in the absence and presence of nifedipine. The results showed that the testosterone derivative increases the LVP in a dose-dependent manner and this effect was not inhibited in the presence of nifedipine. Each bar represents the mean ± SE of 9 experiments. LVP: left ventricular pressure.