Activity Exerted by a Testosterone Derivative on Myocardial Injury Using an Ischemia/Reperfusion Model
Figure 9
Effects induced by the testosterone derivative on LVP through prostaglandins synthesis and thromboxane receptor. Intracoronary boluses (50 μL) of the testosterone derivative [0.001 to 100 nM] were administered and the corresponding effect on the LVP was determined in the absence and presence of indomethacin and PINANE TXA2. The results showed that the testosterone derivative increases the LVP in a dose-dependent manner and this effect was significantly inhibited in the presence of indomethacin () and PINANE TXA2 (). Each bar represents the mean ± SE of 9 experiments. LVP: left ventricular pressure.
