A Mushroom Extract Piwep from Phellinus igniarius Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Immune Cell Infiltration in the Spinal Cord
Figure 2
Piwep treatment attenuates EAE-induced mononuclear cell infiltration into the white matter of spinal cord, cerebral cortex, and cerebellum in mice. Three weeks after the initial immunization of MOG, infiltration of mononuclear cells around small vessels in the spinal cord and cerebellum was detected with cresyl violet staining. EAE mice revealed intensive infiltration of mononuclear cells around the white matter of spinal cord (a, b) and cerebellum (c, d). However, Piwep treatment reduced mononuclear cell infiltration into the white matter of the spinal cord and cerebellum. Scale bar represents 100 μm. Data are mean SEM (). compared with Piwep treated group.
