A Mushroom Extract Piwep from Phellinus igniarius Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Immune Cell Infiltration in the Spinal Cord
Figure 5
Piwep treatment attenuates mRNA expression of vascular cell adhesion molecule in the spinal cord of EAE mice. Spinal cord perfused with cold PBS was used for extraction of total RNA. Expression of mRNA was determined with the RT-PCR method. RT-PCR results demonstrated an increase of vascular cell adhesion molecule-1 (VCAM-1) and its ligand, integrin- in MOG-induced EAE mice spinal cord. Piwep significantly inhibited VCAM-1 and integrin- expression in the spinal cord. Data are mean SEM (). compared with Piwep treated group.
