Male and Couple Fertility Impairment due to HPV-DNA Sperm Infection: Update on Molecular Mechanism and Clinical Impact—Systematic Review

Table 1

Data about studies analyzing the clinical impact of HPV infection on fertility outcomes.

Authors (Year)	Number of samples	Spontaneous aborted products: HPV+/HPV−	Electively aborted products: HPV+/HPV−	Incidence of miscarriages in pregnant exposure to HPV 6/11/16/18	Samples of placentas at term: HPV+/HPV−	Incidence of miscarriages in couple with male partner: HPV+/HPV−	Incidence of miscarriages in couple with female partner: HPV+/HPV−	Incidence of miscarriages in couple with both partner: HPV+/HPV−
Hermonat et al. (1997) [26]	40	60%/40%	20%/80%
Matovina et al. (2004) [27]	108	7.4%/92.6%
Dana et al. (2009) [28]	517			6.9%
Skoczynski et al. (2011) [29]	129	17.7%/82.3%^+			24.4%/75.6%^+
Perino et al. (2011) [30]	199 (couple)					66.7%/15%*	40%/13%	100%/15.9%°

⁺𝑃<0.05; ^∗𝑃<0.01; ^∘𝑃<0.00.