Histone Deacetylase Inhibitor Impairs Plasminogen Activator Inhibitor-1 Expression via Inhibiting TNF-<i>α</i>-Activated MAPK/AP-1 Signaling Cascade

<table>Schematic diagram shows that CBHA abrogates TNF-<i>α</i>-induced PAI-1 expression in human pleural mesothelial cells through enhancement of MKP-5/MKP-1 expression and repression of MAPK/AP-1 signal pathway (see test for further explanation). Single arrow, established signal pathway; double arrow, possible signal pathway. (P), phosphorylated.</table>

BioMed Research International

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Figure 5

Figure 5: Histone Deacetylase Inhibitor Impairs Plasminogen Activator Inhibitor-1 Expression via Inhibiting TNF-<i>α</i>-Activated MAPK/AP-1 Signaling Cascade 

Figure 5 | Histone Deacetylase Inhibitor Impairs Plasminogen Activator Inhibitor-1 Expression via Inhibiting TNF-α-Activated MAPK/AP-1 Signaling Cascade 