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BioMed Research International
Volume 2014, Article ID 231236, 5 pages
http://dx.doi.org/10.1155/2014/231236
Research Article

The Association of HLA-Class I and Class II with Hodgkin’s Lymphoma in Iranian Patients

1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran
2Department of Medical Genetics, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran
3Taleghani Bone Marrow Transplantation Center, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran
4Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran

Received 4 February 2014; Revised 16 April 2014; Accepted 1 May 2014; Published 21 May 2014

Academic Editor: Isabel Neuringer

Copyright © 2014 Arezou Sayad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The Hodgkin’s lymphoma disease (HD) is a common malignant neoplasm with germinal centre B-cell origin. It has been suggested that the HLA class I and class II regions have susceptibility effects on HD. In different ethnic groups, different HLA class I and class II alleles affect HD. As a result, there is no consensus which of the different HLA alleles confers susceptibility to HD. In this study, we aimed to ascertain the role of HLA class I and class II alleles in association with Hodgkin’s lymphoma in Iranian patients. We performed a case-control genotyping study in 85 Iranian HD patients which were selected from the Bone Marrow Transplantation Department of Taleghani Hospital and 150 controls using the SSP-PCR. Our results demonstrated that the 68, 51, and 15 alleles were significantly more frequent in HD patients in comparison to controls ( ; OR = 6.188, ; OR = 2.86, ; OR = 5.315, resp.) and they have significant susceptibility effects on HD in Iranian population. There are reports of other populations with regard to consistency and inconsistency to our results. Further studies with large sample size or the meta-analysis are needed to explain the exact associations of HLA gene with HD.