BioMed Research International / 2014 / Article / Tab 4

Review Article

Implications of Heterogeneity in Multiple Myeloma

Table 4

GEP-based prognostic signatures.

GEP signatureMethods

UAMS 70-gene [49]Derived by comparing expression of profiles of patients with top and bottom quartile of survival treated on total therapy II

IFM signature [50]Derived by comparing expression of profiles of patients with good and poor outcome in IFM trials

Centrosome index [51]Based on expression of constituents of the centrosome

HZD cell death signature [52]Signature derived from genes homozygously deleted in myeloma as detected by array comparative genomic hybridization

IL6-HMCL signature [53]13-gene signature from genes induced upon IL6 stimulation of human myeloma cells lines

Proliferation index [54]Curated signature based on proliferation genes

EMC 92-gene signature [55]92-gene signature based on differentially expressed genes between patient with good and poor outcome on HOVON trial

Chromosome instability genomic event count (CINGEC) signature [56]Based on differentially expressed genes between patients with the top and bottom quartile of genomic instability score based on number of genetic abnormalities identified by array comparative genomic hybridization