Implications of Heterogeneity in Multiple Myeloma

Table 6

Subtypes of MPC and their phenotypes described in the key publications.

Study	MPC subpopulation and phenotype
Rasmussen 2000 [74]	Early B cell; CD38+, CD19+	More differentiated B cell; CD38−, CD19+
Boucher et al. 2012 [75]	LCR B-cells; CD138−/CD34+/CD19+	More Differentiated B cells; CD138−/CD34−/CD19+	Plasma cells; CD138+/CD34−/CD19−
Chaidos et al. 2013 [76]	Memory B cells; CD 19+, CD 138−, CD 38−	Plasmablasts; CD 19+, CD 138−, CD38+	Preplasma cells; CD 19−, CD 138−, CD38+, CD56+	Plasma cells; CD 19−, 138dim or +, CD 56+, CD38
Leung-Hagesteijn et al. 2013 [77]	B cell; CD20+, CD38−, CD138−	Activated B-cell; CD20low, CD38−, CD138−	Preplasmablast; CD20−, CD38−, CD138−	Plasmablast; CD20−, CD38+, CD138+/−	Plasma cell; CD20−, CD38+, CD138+

LCR = Light chain restricted.