BioMed Research International / 2014 / Article / Tab 7 / Review Article
Implications of Heterogeneity in Multiple Myeloma Table 7 Summary of differential gene expression between CD 138− and CD 138+ subsets. The list of genes is not exhaustive but includes selected genes of importance described in the studies.
Study Gene Differential expression Function
Reghunathan et al. 2013 [73 ] PRC2 related (EZH2, EED, SUZ12) PRC1 related (BMI1) Upregulated in CD 138− subset. Via histone methylation, reduces the expression of p21 and other CDK inhibitors, driving proliferation. BMP 2, BMP3, BMP4 Upregulated in CD 138+ subset Promote differentiation of plasmablasts to mature plasma cells.
Yang et al. 2013 [78 ] RARα 2 Upregulated in CD 138− subset. Increased ALDH expression, increased activity of WNT and Hedgehog pathway signaling as well as Cyclin D1. Oct 4, SOX 2, Nanog, Lin 28A Upregulated in CD 138− subset Genes expressed in pluripotent stem cells.