Summary of differential gene expression between CD 138− and CD 138+ subsets. The list of genes is not exhaustive but includes selected genes of importance described in the studies.
|Study||Gene ||Differential expression||Function|
Reghunathan et al. 2013 ||PRC2 related|
(EZH2, EED, SUZ12)
|Upregulated in CD 138− subset.||Via histone methylation, reduces the expression of p21 and other CDK inhibitors, driving proliferation. |
|BMP 2, BMP3, BMP4||Upregulated in CD 138+ subset||Promote differentiation of plasmablasts to mature plasma cells.|
Yang et al. 2013 ||RARα2||Upregulated in CD 138− subset.||Increased ALDH expression, increased activity of WNT and Hedgehog pathway signaling as well as Cyclin D1.|
|Oct 4, SOX 2, Nanog, Lin 28A||Upregulated in CD 138− subset||Genes expressed in pluripotent stem cells. |