CNB-001 a Novel Curcumin Derivative, Guards Dopamine Neurons in MPTP Model of Parkinson’s Disease

<table>Photomicrographs of ST sections depicting TH-immunoreactive (TH-ir) fibers. (a) (4X) Administration of MPTP (B) significantly depleted TH-positivity in striatum and this depletion was inhibited by pretreatment with CNB-001 (C). (b) TH immunoreactivity was analyzed by measuring the optical density in ST. Mean value of TH-ir was determined for each group and expressed as percentage control. Values are expressed as mean ± SD for three animals in each group. <svg height="17.825001" id="M20" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 69.150002 17.825001" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to control, <svg height="19.65" id="M21" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 70.224998 19.65" width="70.224998" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to MPTP.</table>

BioMed Research International

fig4

Figure 4

Figure 4: CNB-001 a Novel Curcumin Derivative, Guards Dopamine Neurons in MPTP Model of Parkinson’s Disease 