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BioMed Research International
Volume 2014, Article ID 236361, 9 pages
http://dx.doi.org/10.1155/2014/236361
Research Article

CpG Island Methylator Phenotype and Prognosis of Colorectal Cancer in Northeast China

1Department of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang 150081, China
2Department of Surgery, Cancer Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, China

Received 18 February 2014; Accepted 23 July 2014; Published 28 August 2014

Academic Editor: Fumio Imazeki

Copyright © 2014 Xia Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. C. Compton, “Colorectal carcinoma: diagnostic, prognostic, and molecular features,” Modern Pathology, vol. 16, no. 4, pp. 376–388, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx.
  3. M. P. Coleman, D. Forman, H. Bryant et al., “Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995–2007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry data,” The Lancet, vol. 377, no. 9760, pp. 127–138, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. M. P. Coleman, M. Quaresma, F. Berrino et al., “Cancer survival in five continents: a worldwide population-based study (CONCORD),” The Lancet Oncology, vol. 9, no. 8, pp. 730–756, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Shen, P. J. Catalano, A. B. Benson III, P. O'Dwyer, S. R. Hamilton, and J. J. Issa, “Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil-based chemotherapy,” Clinical Cancer Research, vol. 13, no. 20, pp. 6093–6098, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. M. van Rijnsoever, H. Elsaleh, D. Joseph, K. McCaul, and B. Iacopetta, “CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer,” Clinical Cancer Research, vol. 9, no. 8, pp. 2898–2903, 2003. View at Google Scholar · View at Scopus
  7. S. Ogino and A. Goel, “Molecular classification and correlates in colorectal cancer,” Journal of Molecular Diagnostics, vol. 10, no. 1, pp. 13–27, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. W. M. Grady and J. M. Carethers, “Genomic and epigenetic instability in colorectal cancer pathogenesis,” Gastroenterology, vol. 135, no. 4, pp. 1079–1099, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Issa, “CpG island methylator phenotype in cancer,” Nature Reviews Cancer, vol. 4, no. 12, pp. 988–993, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. J. R. Jass, “Classification of colorectal cancer based on correlation of clinical, morphological and molecular features,” Histopathology, vol. 50, no. 1, pp. 113–130, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Popat, R. Hubner, and R. S. Houlston, “Systematic review of microsatellite instability and colorectal cancer prognosis,” Journal of Clinical Oncology, vol. 23, no. 3, pp. 609–618, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. L. Barault, C. Charon-Barra, V. Jooste et al., “Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases,” Cancer Research, vol. 68, no. 20, pp. 8541–8546, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. J. B. Ahn, W. B. Chung, O. Maeda et al., “DNA methylation predicts recurrence from resected stage III proximal colon cancer,” Cancer, vol. 117, no. 9, pp. 1847–1854, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. A. M. Dahlin, R. Palmqvist, M. L. Henriksson et al., “The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status,” Clinical Cancer Research, vol. 16, no. 6, pp. 1845–1855, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Rhee, M. J. Kim, J. M. Bae et al., “Clinical outcomes of patients with microsatellite-unstable colorectal carcinomas depend on l1 methylation level,” Annals of Surgical Oncology, vol. 19, no. 11, pp. 3441–3448, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Jo, K. Jung, M. Grade et al., “CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer,” Surgery, vol. 151, no. 4, pp. 564–570, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. J. M. Bae, J. H. Kim, N. Y. Cho, T. Kim, and G. H. Kang, “Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumour location,” British Journal of Cancer, vol. 109, no. 4, pp. 1004–1012, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. W. S. Samowitz, K. Curtin, R. K. Wolff, S. R. Tripp, B. J. Caan, and M. L. Slattery, “Microsatellite instability and survival in rectal cancer,” Cancer Causes and Control, vol. 20, no. 9, pp. 1763–1768, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. J. H. Kim, S. H. Shin, H. J. Kwon, N. Y. Cho, and G. H. Kang, “Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers,” Virchows Archiv, vol. 455, no. 6, pp. 485–494, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Lee, N. Cho, M. Choi, E. J. Yoo, J. Kim, and G. H. Kang, “Clinicopathological features of CpG island methylator phenotype-positive colorectal cancer and its adverse prognosis in relation to KRAS/BRAF mutation,” Pathology International, vol. 58, no. 2, pp. 104–113, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Ferracin, R. Gafà, E. Miotto et al., “The methylator phenotype in microsatellite stable colorectal cancers is characterized by a distinct gene expression profile,” Journal of Pathology, vol. 214, no. 5, pp. 594–602, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. J. A. Sanchez, L. Krumroy, S. Plummer et al., “Genetic and epigenetic classifications define clinical phenotypes and determine patient outcomes in colorectal cancer,” British Journal of Surgery, vol. 96, no. 10, pp. 1196–1204, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Kakar, G. Deng, V. Sahai et al., “Clinicopathologic characteristics, CpG island methylator phenotype, and BRAF mutations in microsatellite-stable colorectal cancers without chromosomal instability,” Archives of Pathology and Laboratory Medicine, vol. 132, no. 6, pp. 958–964, 2008. View at Google Scholar · View at Scopus
  24. R. Jover, T. Nguyen, L. Prezcarbonell et al., “5-fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer,” Gastroenterology, vol. 140, no. 4, pp. 1174–1181, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Donada, S. Bonin, R. Barbazza, D. Pettirosso, and G. Stanta, “Management of stage II colon cancer—the use of molecular biomarkers for adjuvant therapy decision,” BMC Gastroenterology, vol. 13, article 36, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Han, H. Lee, J. M. Bae et al., “Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer,” International Journal of Cancer, vol. 132, no. 9, pp. 2209–2216, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. B. Min, J. M. Bae, E. J. Lee et al., “The CpG island methylator phenotype may confer a survival benefit in patients with stage II or III colorectal carcinomas receiving fluoropyrimidine-based adjuvant chemotherapy,” BMC Cancer, vol. 11, article 344, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. W. S. Samowitz, C. Sweeney, J. Herrick et al., “Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers,” Cancer Research, vol. 65, no. 14, pp. 6063–6070, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. M. R. Kohonen-Corish, J. Tseung, and C. Chan, “KRAS mutations and CDKN2A promoter methylation show an interactive adverse effect on survival and predict recurrence of rectal cancer,” International Journal of Cancer, vol. 134, no. 12, pp. 2820–2828, 2014. View at Publisher · View at Google Scholar
  30. J. H. Kim, Y. Y. Rhee, J. M. Bae, N. Y. Cho, and G. H. Kang, “Loss of CDX2/CK20 expression is associated with poorly differentiated carcinoma, the CpG island methylator phenotype, and adverse prognosis in microsatellite-unstable colorectal cancer,” The American Journal of Surgical Pathology, vol. 37, no. 10, pp. 1532–1541, 2013. View at Publisher · View at Google Scholar
  31. N. J. Samadder, R. A. Vierkant, L. S. Tillmans et al., “Associations between colorectal cancer molecular markers and pathways with clinicopathologic features in older women,” Gastroenterology, vol. 145, no. 2, pp. 348–356, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. R. L. Ward, K. Cheong, S. L. Ku, A. Meagher, T. O'Connor, and N. J. Hawkins, “Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability,” Journal of Clinical Oncology, vol. 21, no. 20, pp. 3729–3736, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Ogino, K. Nosho, G. J. Kirkner et al., “CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer,” Gut, vol. 58, no. 1, pp. 90–96, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. L. H. Sobin and I. D. Fleming, “TNM Classification of Malignant Tumors, fifth edition (1997). Union Internationale Contre le Cancer and the American Joint Committee on Cancer,” Cancer, vol. 80, no. 9, pp. 1803–1804, 1997. View at Google Scholar
  35. S. R. Hamilton and L. A. Aaltonen, World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Digestive System, IARC Press, Lyon, France, 2000.
  36. D. J. Weisenberger, K. D. Siegmund, M. Campan et al., “CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer,” Nature Genetics, vol. 38, no. 7, pp. 787–793, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. L. A. E. Hughes, C. A. J. Khalid-de Bakker, K. M. Smits et al., “The CpG island methylator phenotype in colorectal cancer: progress and problems,” Biochimica et Biophysica Acta—Reviews on Cancer, vol. 1825, no. 1, pp. 77–85, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. A. Goel, T. Nagasaka, C. N. Arnold et al., “The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer,” Gastroenterology, vol. 132, no. 1, pp. 127–138, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Ogino, J. A. Meyerhardt, T. Kawasaki et al., “CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma,” Virchows Archiv, vol. 450, no. 5, pp. 529–537, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. T. Hinoue, D. J. Weisenberger, C. P. E. Lange et al., “Genome-scale analysis of aberrant DNA methylation in colorectal cancer,” Genome Research, vol. 22, no. 2, pp. 271–282, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. K. Bardhan and K. Liu, “Epigenetics and colorectal cancer pathogenesis,” Cancers, vol. 5, no. 2, pp. 676–713, 2013. View at Publisher · View at Google Scholar · View at Scopus
  42. Y. S. Kim and G. Deng, “Epigenetic changes (aberrant DNA methylation) in colorectal neoplasia,” Gut Liver, vol. 1, no. 1, pp. 1–11, 2007. View at Google Scholar
  43. D. Colussi, G. Brandi, and F. Bazzoli, “Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention,” International Journal of Molecular Sciences, vol. 14, no. 8, pp. 16365–16385, 2013. View at Publisher · View at Google Scholar
  44. S. Ogino, A. T. Chan, C. S. Fuchs, and E. Giovannucci, “Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field,” Gut, vol. 60, no. 3, pp. 397–411, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. K. Curtin, M. L. Slattery, and W. S. Samowitz, “CpG island methylation in colorectal cancer: past, present and future,” Pathology Research International, vol. 2011, Article ID 902674, 8 pages, 2011. View at Publisher · View at Google Scholar
  46. J. H. Kim and G. H. Kang, “Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer,” World Journal of Gastroenterology, vol. 20, no. 15, pp. 4230–4243, 2014. View at Google Scholar
  47. A. E. Noffsinger, “Serrated polyps and colorectal cancer: new pathway to malignancy,” Annual Review of Pathology, vol. 4, pp. 343–364, 2009. View at Publisher · View at Google Scholar · View at Scopus
  48. D. C. Snover, “Update on the serrated pathway to colorectal carcinoma,” Human Pathology, vol. 42, no. 1, pp. 1–10, 2011. View at Publisher · View at Google Scholar · View at Scopus
  49. M. Toyota, N. Ahuja, M. Ohe-Toyota, J. G. Herman, S. B. Baylin, and J. J. Issa, “CpG island methylator phenotype in colorectal cancer,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 15, pp. 8681–8686, 1999. View at Publisher · View at Google Scholar · View at Scopus
  50. P. A. Jones and S. B. Baylin, “The fundamental role of epigenetic events in cancer,” Nature Reviews Genetics, vol. 3, no. 6, pp. 415–428, 2002. View at Google Scholar · View at Scopus
  51. I. J. H. van Vlodrop, H. E. C. Niessen, S. Derks et al., “Analysis of promoter CpG island hypermethylation in cancer: location, location, location!,” Clinical Cancer Research, vol. 17, no. 13, pp. 4225–4231, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. T. K. Wojdacz, A. Dobrovic, and L. L. Hansen, “Methylation-sensitive high-resolution melting,” Nature Protocols, vol. 3, no. 12, pp. 1903–1908, 2008. View at Publisher · View at Google Scholar · View at Scopus
  53. W. Meng, A. Huebner, A. Shabsigh, A. Chakravarti, and T. Lautenschlaeger, “Combined RASSF1A and RASSF2A promoter methylation analysis as diagnostic biomarker for bladder cancer,” Molecular Biology International, vol. 2012, Article ID 701814, 8 pages, 2012. View at Publisher · View at Google Scholar
  54. M. Balic, M. Pichler, J. Strutz et al., “High quality assessment of DNA methylation in archival tissues from colorectal cancer patients using quantitative high-resolution melting analysis,” Journal of Molecular Diagnostics, vol. 11, no. 2, pp. 102–108, 2009. View at Publisher · View at Google Scholar · View at Scopus
  55. L. Morandi, E. Franceschi, D. de Biase et al., “Promoter methylation analysis of O6-methylguanine-DNA methyltransferase in glioblastoma: detection by locked nucleic acid based quantitative PCR using an imprinted gene (SNURF) as a reference,” BMC Cancer, vol. 10, article 48, 2010. View at Publisher · View at Google Scholar · View at Scopus
  56. A. Avraham, R. Uhlmann, A. Shperber et al., “Serum DNA methylation for monitoring response to neoadjuvant chemotherapy in breast cancer patients,” International Journal of Cancer, vol. 131, no. 7, pp. E1166–E1172, 2012. View at Publisher · View at Google Scholar · View at Scopus
  57. L. S. Kristensen, T. Mikeska, M. Krypuy, and A. Dobrovic, “Sensitive melting analysis after real time-methylation specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection,” Nucleic Acids Research, vol. 36, no. 7, article e42, 2008. View at Publisher · View at Google Scholar · View at Scopus
  58. S. Ogino, T. Kawasaki, G. J. Kirkner, M. Loda, and C. S. Fuchs, “CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations,” Journal of Molecular Diagnostics, vol. 8, no. 5, pp. 582–588, 2006. View at Publisher · View at Google Scholar · View at Scopus
  59. K. Nosho, N. Irahara, K. Shima et al., “Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample,” PLoS ONE, vol. 3, no. 11, Article ID e3698, 2008. View at Publisher · View at Google Scholar · View at Scopus
  60. S. Ogino, T. Kawasaki, G. J. Kirkner, Y. Suemoto, J. A. Meyerhardt, and C. S. Fuchs, “Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer,” Gut, vol. 56, no. 11, pp. 1564–1571, 2007. View at Publisher · View at Google Scholar · View at Scopus
  61. T. Kawasaki, M. Ohnishi, K. Nosho et al., “CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci,” Modern Pathology, vol. 21, no. 3, pp. 245–255, 2008. View at Publisher · View at Google Scholar · View at Scopus
  62. M. Esteller, A. Sparks, M. Toyota et al., “Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer,” Cancer Research, vol. 60, no. 16, pp. 4366–4371, 2000. View at Google Scholar · View at Scopus
  63. M. O. Hiltunen, L. Alhonen, J. Koistinaho et al., “Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma,” International Journal of Cancer, vol. 70, no. 6, pp. 644–648, 1997. View at Google Scholar
  64. S. Chen, S. Chiu, C. Wu et al., “The association of methylation in the promoter of APC and MGMT and the prognosis of Taiwanese CRC patients,” Genetic Testing and Molecular Biomarkers, vol. 13, no. 1, pp. 67–71, 2009. View at Publisher · View at Google Scholar · View at Scopus
  65. J. G. Herman, J. R. Graff, S. Myöhänen, B. D. Nelkin, and S. B. Baylin, “Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 18, pp. 9821–9826, 1996. View at Publisher · View at Google Scholar · View at Scopus
  66. S. Lee, N. Cho, E. J. Yoo, J. H. Kim, and G. H. Kang, “CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CPG island methylator phenotype marker panels,” Archives of Pathology and Laboratory Medicine, vol. 132, no. 10, pp. 1657–1665, 2008. View at Google Scholar · View at Scopus
  67. D. R. English, J. P. Young, J. A. Simpson et al., “Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype,” Cancer Epidemiology Biomarkers and Prevention, vol. 17, no. 7, pp. 1774–1780, 2008. View at Publisher · View at Google Scholar · View at Scopus
  68. J. C. Kim, J. S. Choi, S. A. Roh, D. H. Cho, T. W. Kim, and Y. S. Kim, “Promoter methylation of specific genes is associated with the phenotype and progression of colorectal adenocarcinomas,” Annals of Surgical Oncology, vol. 17, no. 7, pp. 1767–1776, 2010. View at Publisher · View at Google Scholar · View at Scopus