BioMed Research International / 2014 / Article / Tab 3

Research Article

CpG Island Methylator Phenotype and Prognosis of Colorectal Cancer in Northeast China

Table 3

Survival analysis on CRC patients according to methylation of individual methylation marker and CIMP status in tumor tissue.

Number of patientsNumber of deathsOverall survival (%)UnivariateMultivariate
3 y5 y7 yHR and 95% CIHR and 95% CI

 Methylation712469.0064.0064.000.94 (0.59–1.48)0.771.07 (0.66–1.74)0.79
 Methylation983568.0056.0056.001.02 (0.68–1.54)0.931.05 (0.69–1.61)0.81
 Methylation562167.0047.0047.001.27 (0.78–2.05)0.341.05 (0.64–1.73)0.85
 Methylation753367.0044.0034.001.46 (0.96–2.21)0.081.61 (1.05–2.46)0.03
 Methylation592462.0053.0053.001.36 (0.86–2.16)0.191.38 (0.85–2.24)0.20
 Methylation1364869.0059.0054.001.04 (0.70–1.54)0.841.01 (0.67–1.53)0.96
 Methylation541773.0055.0055.000.90 (0.53–1.52)0.691.14 (0.67–1.95)0.63
CIMP status
 CIMP-L 2097072.0061.0054.000.99 (0.53–1.82)0.960.95 (0.60–1.52)0.84
 CIMP-H 371858.0033.0033.001.71 (0.82–3.55)0.153.06 (1.19–7.89)0.02
 CIMP-H versus CIMP-L 1.78 (1.07–3.03)0.03 1.97 (1.11–3.48)0.02
 CIMP-H versus CIMP-L
 and CIMP-0
1.80 (1.08–3.00)0.032.31 (1.02–5.24)0.04

Multivariate analysis, adjusted for age at diagnosis, tumor stage, tumor differentiation, and tumor location.

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