BioMed Research International / 2014 / Article / Tab 3

Research Article

CpG Island Methylator Phenotype and Prognosis of Colorectal Cancer in Northeast China

Table 3

Survival analysis on CRC patients according to methylation of individual methylation marker and CIMP status in tumor tissue.

Number of patientsNumber of deathsOverall survival (%)UnivariateMultivariate
3 y5 y7 yHR and 95% CIHR and 95% CI

MLH1
 Unmethylation2117671.0056.0048.00Ref.Ref.
 Methylation712469.0064.0064.000.94 (0.59–1.48)0.771.07 (0.66–1.74)0.79
MGMT
 Unmethylation1846572.0059.0050.00Ref.Ref.
 Methylation983568.0056.0056.001.02 (0.68–1.54)0.931.05 (0.69–1.61)0.81
p16
 Unmethylation2267972.0060.0053.00Ref.Ref.
 Methylation562167.0047.0047.001.27 (0.78–2.05)0.341.05 (0.64–1.73)0.85
APC
 Unmethylation2076772.0063.0059.00Ref.Ref.
 Methylation753367.0044.0034.001.46 (0.96–2.21)0.081.61 (1.05–2.46)0.03
MINT1
 Unmethylation2237673.0059.0051.00Ref.Ref.
 Methylation592462.0053.0053.001.36 (0.86–2.16)0.191.38 (0.85–2.24)0.20
MINT31
 Unmethylation1465272.0056.0050.00Ref.Ref.
 Methylation1364869.0059.0054.001.04 (0.70–1.54)0.841.01 (0.67–1.53)0.96
RUNX3
 Unmethylation2288370.0058.0051.00Ref.Ref.
 Methylation541773.0055.0055.000.90 (0.53–1.52)0.691.14 (0.67–1.95)0.63
CIMP status
 CIMP-0361277.0059.0059.00Ref.Ref.
 CIMP-L 2097072.0061.0054.000.99 (0.53–1.82)0.960.95 (0.60–1.52)0.84
 CIMP-H 371858.0033.0033.001.71 (0.82–3.55)0.153.06 (1.19–7.89)0.02
 CIMP-H versus CIMP-L 1.78 (1.07–3.03)0.03 1.97 (1.11–3.48)0.02
 CIMP-H versus CIMP-L
 and CIMP-0
1.80 (1.08–3.00)0.032.31 (1.02–5.24)0.04

Multivariate analysis, adjusted for age at diagnosis, tumor stage, tumor differentiation, and tumor location.

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