MicroRNA Dysregulation in Liver and Pancreas of CMP-Neu5Ac Hydroxylase Null Mice Disrupts Insulin/PI3K-AKT Signaling

Table 1

Target genes of dysregulated miRNAs identified in Cmah-null mice.

miRNA	KEGG pathway	value	Target genes
miR-155-5p, miR-15a-5p, let-7c-5p, miR-106b-5p, let-7b-5p, miR-27b-9p	Acute myeloid leukemia	0.0280	8
miR-15a-5p, miR-425-5p	Aldosterone-regulated sodium reabsorption	0.0143	4
miR-29b-3p, miR-29a-3p, miR-24-3p	Amoebiasis	0.0000	6
miR-155-5p, miR-503-5p, miR-16-5p, miR-425-5p	Apoptosis	0.0008	6
miR-140-5p, let-7b-5p, miR-24-3p	Axon guidance	0.0007	9
miR-15a-5p, let-7b-5p	B cell receptor signaling pathway	0.0029	7
miR-29a-3p	Bacterial invasion of epithelial cells	0.0296	1
miR-425-5p	Carbohydrate digestion and absorption	0.0091	4
miR-15a-5p, miR-425-5p, miR-24-3p, miR-23b-3p, miR-27b-13p	Chagas disease (American trypanosomiasis)	0.0020	9
miR-335-5p, miR-15a-5p, let-7c-5p, let-7b-5p, miR-425-5p, miR-23b-3p, miR-27b-3p, miR-27a-3p	Chronic myeloid leukemia	0.0061	10
miR-425-5p	Circadian rhythm	0.0032	3
miR-503-5p, miR-15a-5p, let-7c-5p, miR-16-5p, let-7b-5p, miR-425-5p, miR-24-3p, miR-23b-3p, miR-27b-6p	Colorectal cancer	0.0007	9
miR-29b-3p, miR-29a-3p, miR-27a-3p	Cysteine and methionine metabolism	0.0012	2
miR-503-5p, let-7a-5p, miR-29b-3p	Cytokine-cytokine receptor interaction	0.0002	3
miR-155-5p	Cytosolic DNA-sensing pathway	0.0052	2
let-7d-5p, miR-425-5p, miR-24-3p	Dopaminergic synapse	0.0045	9
miR-15a-5p	Dorsoventral axis formation	0.0105	3
miR-29b-3p, miR-29a-3p	ECM-receptor interaction	0.0000	5
miR_142-3p, miR-425-5p	Endocrine and other factor-regulated calcium reabsorption	0.0216	1
miR-15a-5p, let-7c-5p, let-7b-5p, miR-425-5p	Endometrial cancer	0.0012	6
miR-155-5p, miR-335-5p, miR-106b-5p	Epstein-Barr virus infection	0.0240	3
miR-15a-5p	Fatty acid biosynthesis	0.0000	1
miR-15a-5p	Fc gamma R-mediated phagocytosis	0.0103	7
miR-15a-5p, miR-16-5p, miR-29b-3p, miR-29a-3p, let-7b-5p, mmu-miR-425-5p	Focal adhesion	0.0105	12
miR_142-3p, let-7b-5p, miR-425-5p	GABAergic synapse	0.0216	9
miR_142-3p, miR-15a-5p, miR-425-5p	Gap junction	0.0230	7
miR_142-3p, miR-425-5p, miR-24-3p	Gastric acid secretion	0.0216	5
miR-15a-5p	Glycosaminoglycan biosynthesis-heparan sulfate/heparin	0.0000	3
miR-15a-5p	Glycosphingolipid biosynthesis-globo series	0.0209	2
miR-15a-5p, let-7b-5p, miR-24-3p	Glycosphingolipid biosynthesis-lacto and neolacto series	0.0004	3
let-7b-5p	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0.0017	3
miR_142-3p, miR-15a-5p, miR-106b-5p, miR-24-3p	GnRH signaling pathway	0.0216	6
miR-16-5p, miR-106b-5p, miR-425-5p	Hedgehog signaling pathway	0.0454	5
miR-503-5p, miR-335-5p, miR-15a-5p, let-7c-5p, miR-16-5p, miR-106b-5p, miR-20a-5p, let-7b-5p, miR-425-5p	Hepatitis B	0.0008	14
miR-155-5p, miR-15a-5p, miR-106b-5p, miR-20a-5p, let-7b-5p	Hepatitis C	0.0339	9
miR-155-5p	Herpes simplex infection	0.0145	3
miR-503-5p, miR-199a-5p, miR-15a-5p, miR-24-3p	HIF-1 signaling pathway	0.0175	2
miR-155-5p, miR-335-5p, let-7c-5p, miR-23b-3p, miR-27b-12p	HTLV-I infection	0.0145	3
miR-155-5p, iR-15a-5p, miR-425-5p	Insulin signaling pathway	0.0339	10
miR-155-5p, miR-140-5p	Intestinal immune network for IgA production	0.0339	2
miR-15a-5p, miR-425-5p, miR-24-3p	Long-term depression	0.0005	7
miR-15a-5p, miR-24-3p	Lysine degradation	0.0196	4
let-7d-5p, let-7b-5p, miR-425-5p	MAPK signaling pathway	0.0073	12
miR-503-5p, let-7a-5p	Measles	0.0435	2
miR-199a-5p, miR-15a-5p, miR-425-5p	mTOR signaling pathway	0.0006	6
miR-155-5p, miR-140-5p	NF-kappa B signaling pathway	0.0038	2
miR-503-5p	p53 signaling pathway	0.0047	2
miR-155-5p, miR-503-5p, miR-199a-5p, miR-15a-5p, let-7c-5p, miR-16-5p, miR-106b-5p, miR-20a-5p, let-7b-5p, miR-425-5p, miR-23b-3p, miR-27b-4p, miR-27a-3p	Pathways in cancer	0.0064	20
miR-503-5p, miR-15a-5p, miR-16-5p, miR-29b-3p, miR-29a-3p	PI3K-AKT signaling pathway	0.0060	18
miR-29b-3p, miR-29a-3p	Protein digestion and absorption	0.0000	5
miR_142-3p, miR-106b-5p, miR-425-5p, miR-24-3p	Retrograde endocannabinoid signaling	0.0207	7
miR-15a-5p, let-7b-5p	T cell receptor signaling pathway	0.0392	7
miR-503-5p, miR-15a-5p, let-7c-5p, miR-140-5p, miR-34c-5p, miR-29b-3p, miR-24-3p, miR-23b-3p, miR-27b-3p	TGF-beta signaling pathway	0.0000	6
miR-155-5p	Toll-like receptor signaling pathway	0.0000	4
miR-155-5p, miR-503-5p, miR-16-5p, miR-106b-5p, miR-20a-5p	Toxoplasmosis	0.0294	2
miR-155-5p, miR-503-5p, miR-196a-5p, let-7a-5p, let-7c-5p, miR-34c-5p, miR-27b-5p, miR-27a-3p	Transcriptional misregulation in cancer	0.0052	3
miR-155-5p	Tuberculosis	0.0072	3
miR_142-3p, miR-15a-5p	Vasopressin-regulated water reabsorption	0.0207	5
miR-15a-5p, miR-425-5p, miR-106b-5p	VEGF signaling pathway	0.0045	6
miR-503-5p, miR-335-5p	Viral carcinogenesis	0.0044	3
let-7c-5p, miR-140-5p, miR-16-5p, miR-24-3p, miR-23b-3p, miR-27b-11p	Wnt signaling pathway	0.0398	6

Bold text represents significantly downregulated miRNAs.