Association between 𝜺2/3/4, Promoter Polymorphism (−491A/T, −427T/C, and −219T/G) at the Apolipoprotein E Gene, and Mental Retardation in Children from an Iodine Deficiency Area, China

Table 3

Estimated haplotype frequencies for linkage disequilibrium among ApoE −491,  −427, −219, and 𝜀2/𝜀3/𝜀4.

Haplotype^a	Frequency	MR; (𝑁=260)	Borderline MR; (𝑁=248)	Control; (𝑁=668)	Mantel-Haenszel 𝜒^2	𝑃 value^b
						Uncorrected	Corrected
ATTε2	0.06	0.07	0.02	0.06	0.0005	0.98	1.00
ATGε3	0.19	0.19	0.22	0.18	0.37	0.54	1.00
ATTε3	0.55	0.51	0.60	0.55	0.40	0.53	1.00
ATTε4	0.07	0.10	0.07	0.05	8.09	0.004	0.02
ACGε2	0.02	0.01	0.06	0.02	0.03	0.87	1.00
ACGε3	0.06	0.08	0.01	0.07	0.07	0.80	1.00

aHaplotypes are from alleles of 4 polymorphisms: ApoE −491, −427, −219, and 𝜀2/3/4. Only the haplotypes with frequency 0.01 and higher are shown.
^bCorrected 𝑃 value according to Bonferroni correction (6 tests).