BioMed Research International / 2014 / Article / Tab 7 / Review Article
Pharmacological Strategies to Prevent Contrast-Induced Acute Kidney Injury Table 7 Prospective, randomized clinical trials comparing efficacy of dopamine with placebo and other agents for contrast-induced AKI after angiography prophylaxis.
Authors Year Type of procedure and contrast media Number of patients Intervention versus control Study protocol Intravascular volume expansion and NAC protocol CI-AKI definition Mean GFR Intervention versus control (mL/min/1.73 m2 ) Incidence of CI-AKI RRT requirement Intervention versus control (%) Intervention Control Intervention versus control (%)
valueHans et al. [100 ] 1998 PAG Iohexol 28 versus 27 Dopamine 2.5 mcg/kg/h 1 hour before and 11 hours after NSS None ↑Cr ≥0.5/2 days 42.18 versus 48.8 7.1 versus 28.6 0.026 ND Kapoor et al. [99 ] 1996 CAG Urograffin 20 versus 20 Dopamine 5 mcg/kg/h 30 minutes before and 6–8 hours after None None ↑Cr ≥25%/1 day ↑Cr ≥25%/3 days
*Cr 1.50 versus 1.52 0 versus 50 ND 0 versus 0 Abizaid et al. [101 ] 1999 CAG Hexabrix 20 versus 20 versus 20 Dopamine 2.5 mcg/kg/h (1) None (2) Aminophylline IV 4 mg/kg then 0.4 mg/kg/h N/2 1 mL/kg/h 12 hours before and after ↑Cr ≥25%/2 days
*Cr 1.9 versus 2.3 versus 1.9 50 versus 30 versus 35 0.60 0 versus 0 versus 5 Stevens et al. [102 ] 1999 CAG ND 22 versus 21 versus 55 Dopamine 3 mcg/kg/h, Furosemide 1 mg/kg IV before, and Mannitol 12.5 g in D5W 250 mL IV in 2 hours (1) Dopamine 3 mcg/kg/h and Furosemide 1 mg/kg IV before (2) None N/2 150 mL/h 6 hours after then adjust to match urine output ↑Cr ≥25%/0.5–2 days 33.73 versus 31.44 versus 30.48 31.8 versus 33.3 versus 30.9 0.98 4.5 versus 4.8 versus 9.1
*Mean GFR data is not available. Data is shown as mean serum creatinine in mg/dL. CAG: coronary angiography; CI-AKI: contrast-induced acute kidney injury; Cr: creatinine; g: gram; D5W: 5% dextrose solution; h: hour; IV: intravenous; kg: kilogram body weight; mcg: microgram; mg: milligram; mL: milliliter, NAC: N-acetylcysteine; ND: no data; N/2: 0.45% NaCl; PAG: peripheral angiography; po: per oral route; q12h: every 12 hours; RRT: renal replacement therapy.