Mitochondrial Aging and Age-Related Dysfunction of Mitochondria
Figure 1
Different ultrastructural appearances of mitochondria in the aortic intima ((a)–(f)). (a) A typical appearance of a mitochondrion in a grossly normal aorta. (b) A mitochondrion with well-defined cristae and well-preserved surrounding membranes in a lipofibrous plaque. ((c)–(f)) Structural variants and destructive alterations of cristae of mitochondria in lipofibrous plaques. In ((c)–(f)), the formation of vacuole-like structures in zones of oedematous matrix of mitochondria is shown by arrows. ((a)–(f)) Electron microscopy scales = 200 nm (reprinted from Atherosclerosis; Sobenin et al. Changes of mitochondria in atherosclerosis: possible determinant in the pathogenesis of the disease 2013; 227 : 283–288 [38], with permission from Elsevier).
