Identification of Influenza A/H7N9 Virus Infection-Related Human Genes Based on Shortest Paths in a Virus-Human Protein Interaction Network

Table 3

GO term enrichment analysis of the 20 potential H7N9 infection-related human proteins (data not shown of GO terms with number of related proteins below 3) and comparisons with HRV and RSV for these terms.

GO terms	H7N9		HRV		RSV
	Number of proteins	Percentage accounting for the 20 proteins (%)	Number of proteins*	Percentage accounting for the 11 proteins (%)*	Number of proteins*	Percentage accounting for the 44 proteins (%)*
GO:0005515 protein binding	15	75.00	11	100.00	42	95.45
GO:0005829 cytosol	13	65.00	7	63.64	23	52.27
GO:0005737 cytoplasm	11	55.00	6	54.55	30	68.18
GO:0005634 nucleus	9	45.00	4	36.36	33	75.00
GO:0044281 small molecule metabolic process	9	45.00	1	9.09	2	4.55
GO:0003723 RNA binding	8	40.00	4	36.36	2	4.55
GO:0005975 carbohydrate metabolic process	8	40.00	—	—	—	—
GO:0005654 nucleoplasm	7	35.00	7	63.64	19	43.18
GO:0010467 gene expression	7	35.00	8	72.73	6	13.64
GO:0006006 glucose metabolic process	5	25.00	—	—	2	4.55
GO:0005886 plasma membrane	4	20.00	4	36.36	27	61.36
GO:0005622 intracellular	4	20.00	3	27.27	7	15.91
GO:0005643 nuclear pore	4	20.00	1	9.09	—	—
GO:0016032 viral reproduction	4	20.00	8	72.73	4	9.09
GO:0016070 RNA metabolic process	4	20.00	4	36.36	1	2.27
GO:0006094 gluconeogenesis	4	20.00	—	—	—	—
GO:0006096 glycolysis	4	20.00	—	—	—	—
GO:0055085 transmembrane transport	4	20.00	—	—	1	2.27
GO:0005625 soluble fraction	3	15.00	—	—	5	11.36
GO:0008270 zinc ion binding	3	15.00	2	18.18	11	25.00
GO:0016071 mRNA metabolic process	3	15.00	4	36.36	1	2.27
GO:0006606 protein import into nucleus	3	15.00	1	9.09	1	2.27
GO:0005524 ATP binding	3	15.00	1	9.09	14	31.82
GO:0006406 mRNA export from nucleus	3	15.00	1	9.09	—	—
GO:0008286 insulin receptor signaling pathway	3	15.00	1	9.09	4	9.09
GO:0005215 transporter activity	3	15.00	—	—	—	—
GO:0015991 ATP hydrolysis coupled proton transport	3	15.00	—	—	—	—
GO:0015992 proton transport	3	15.00	—	—	—	—
GO:0019221 cytokine-mediated signaling pathway	3	15.00	2	18.18	1	2.27

∗—: no proteins having the GO term was picked out as potential infection-related proteins for the virus.