Table 3: GO term enrichment analysis of the 20 potential H7N9 infection-related human proteins (data not shown of GO terms with number of related proteins below 3) and comparisons with HRV and RSV for these terms.

GO termsH7N9HRVRSV
Number of proteinsPercentage accounting for the 20 proteins (%)Number of proteins*Percentage accounting for the 11 proteins (%)*Number of proteins*Percentage accounting for the 44 proteins (%)*

GO:0005515 protein binding1575.0011100.004295.45
GO:0005829 cytosol1365.00763.642352.27
GO:0005737 cytoplasm1155.00654.553068.18
GO:0005634 nucleus945.00436.363375.00
GO:0044281 small molecule metabolic process945.0019.0924.55
GO:0003723 RNA binding840.00436.3624.55
GO:0005975 carbohydrate metabolic process840.00
GO:0005654 nucleoplasm735.00763.641943.18
GO:0010467 gene expression735.00872.73613.64
GO:0006006 glucose metabolic process525.0024.55
GO:0005886 plasma membrane420.00436.362761.36
GO:0005622 intracellular420.00327.27715.91
GO:0005643 nuclear pore420.0019.09
GO:0016032 viral reproduction420.00872.7349.09
GO:0016070 RNA metabolic process420.00436.3612.27
GO:0006094 gluconeogenesis420.00
GO:0006096 glycolysis420.00
GO:0055085 transmembrane transport420.0012.27
GO:0005625 soluble fraction315.00511.36
GO:0008270 zinc ion binding315.00218.181125.00
GO:0016071 mRNA metabolic process315.00436.3612.27
GO:0006606 protein import into nucleus315.0019.0912.27
GO:0005524 ATP binding315.0019.091431.82
GO:0006406 mRNA export from nucleus315.0019.09
GO:0008286 insulin receptor signaling pathway315.0019.0949.09
GO:0005215 transporter activity315.00
GO:0015991 ATP hydrolysis coupled proton transport315.00
GO:0015992 proton transport315.00
GO:0019221 cytokine-mediated signaling pathway315.00218.1812.27

—: no proteins having the GO term was picked out as potential infection-related proteins for the virus.