Protective Effect of Ethanolic Extract of Tabernaemontana divaricata (L.) R. Br. against DEN and Fe NTA Induced Liver Necrosis in Wistar Albino Rats
Table 3
Changes in the level of lipid peroxidation and enzymatic antioxidants in liver.
Particulars
Control (Group I)
DEN + Fe-NTA (Group II)
DEN & Fe-NTA + plant extract (200 mg/kg) (Group III)
DEN & Fe-NTA + plant extract (400 mg/kg) (Group IV)
Plant extract alone (200 mg/kg) (Group V)
Plant extract alone (400 mg/kg) (Group VI)
DEN & Fe-NTA + Std drug (GroupVII)
Lipid peroxidation in liver
1.56 ± 0.06a
4.95 ± 0.14b
2.56 ± 0.08c
1.74 ± 0.09d
1.58 ± 0.06a
1.54 ± 0.06a
1.59 ± 0.06a
SOD
11.08 ± 0.46a
6.19 ± 0.30b
9.96 ± 0.23c
10.92 ± 0.54a
11.39 ± 0.22a
12.62 ± 0.28a
10.41 ± 0.42a
Catalase
6.01 ± 0.05a
3.25 ± 0.26b
4.33 ± 0.08c
6.04 ± 0.09a
5.96 ± 0.07a
6.19 ± 0.07a
6.03 ± 0.03a
PX
40.22 ± 0.59a
16.85 ± 0.91b
35.64 ± 0.16c
39.33 ± 0.65d
39.30 ± 0.38d
38.94 ± 0.4d
39.19 ± 0.34d
GST
131.22 ± 2.7a
98.08 ± 2.84b
112.86 ± 2.62c
130.07 ± 0.60a
130.66 ± 1.27a
132.56 ± 0.65a
131.08 ± 1.99a
G6PD
13.95 ± 0.11a
5.46 ± 0.24b
8.67 ± 0.09c
13.51 ± 0.4a
13.8 ± 0.21a
13.88 ± 0.12a
13.7 ± 0.18a
GPx
43.94 ± 0.34a
21.58 ± 0.59b
30.64 ± 0.24c
45.06 ± 0.59d
45.54 ± 0.44d
46.59 ± 0.39e
46.16 ± 0.7e
Values are expressed as mean ± SD (). Values not sharing the common superscript differ significantly (DMRT). Units are as follows: SOD—unit/mg protein; CAT—µ moles of H2O2 consumed/min/mg protein; Px—units/g tissue: LPO—nmoles of MDA formed/mg protein.