Review Article
Animal Models in Studies of Cardiotoxicity Side Effects from Antiblastic Drugs in Patients and Occupational Exposed Workers
Table 1
Effects of antiblastic drugs on heart.
| Drugs | CHF* | ECG change | Bradycardia | Ischemia | Arrythmias | Myo/pericarditis | Hypotension | Hypertension |
| Anthracyclines | ++ | ++ | | | + | + | | | Trastuzumab | ++ | | | | | | | | 5-FU | + | + | | ++ | + | | | | Cisplatin | | ++ | | ++ | | | | ++ | Bleomycin | | + | | | | + | | | Cyclophosphamide | +++ | ++ | | | | ++ | | | Methotrexate | | + | | | | | + | | Doxorubicin | + | + | | | | | | + | Taxoids (paclitaxel) | | ++ | + | + | ++ | | + | | Mitoxantrone | | | | | + | | + | | TKIs (sorafenib, sunitinib, etc.) | +++ | | | | | | | ++ |
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CHF: congestive heart failure.
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