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BioMed Research International
Volume 2014, Article ID 247054, 7 pages
http://dx.doi.org/10.1155/2014/247054
Research Article

Endothelium-Independent Vasorelaxant Effects of Hydroalcoholic Extract from Nigella sativa Seed in Rat Aorta: The Roles of Ca2+ and K+ Channels

1Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran
2Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran
3Neurogenic Inflammation Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran

Received 4 February 2014; Revised 13 April 2014; Accepted 21 April 2014; Published 12 May 2014

Academic Editor: Karim Bendjelid

Copyright © 2014 Saeed Niazmand et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [8 citations]

The following is the list of published articles that have cited the current article.

  • Lhoussaine Hajj, Bachir El Bouhali, Morad Hebi, Naoufel Zeggwagh, and Mohamed Eddouks, “Cardiovascular effect of Nigella sativa L. Aqueous extract in normal rats,” Cardiovascular and Hematological Disorders - Drug Targets, vol. 16, no. 1, pp. 47–55, 2016. View at Publisher · View at Google Scholar
  • Amal Akour, Violet Kasabri, Fatma U. Afifi, and Nailya Bulatova, “The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology,” Pharmaceutical Biology, pp. 1–18, 2016. View at Publisher · View at Google Scholar
  • Sara S. Al Disi, M. Akhtar Anwar, and Ali H. Eid, “Anti-hypertensive Herbs and their Mechanisms of Action: Part I,” Frontiers in Pharmacology, vol. 6, 2016. View at Publisher · View at Google Scholar
  • Mahmoud Hosseini, Saeed Niazmand, Elahe Fereidouni, and Maryam Mahmoudabady, “Teucrium polium-induced vasorelaxation mediated by endothelium-dependent and endothelium-independent mechanisms in isolated rat thoracic aorta,” Pharmacognosy Research, vol. 9, no. 4, pp. 372–377, 2017. View at Publisher · View at Google Scholar
  • Rabia Latif, and Al-Asoom Li, “Vasoreactivity of thoracic aorta in Nigella Sativa supplemented and/or exercise trained rats,” Artery Research, vol. 21, pp. 38–42, 2018. View at Publisher · View at Google Scholar
  • Ni Made Dwi Purnamayanti, Siti Candra Windu, and Sri Poeranto, “Effect of nigella sativa ethanol extract on the nitric oxide content and renal arteriole diameter of a pre-eclampsia mouse model,” Eurasian Journal of Medicine, vol. 50, no. 3, pp. 148–151, 2018. View at Publisher · View at Google Scholar
  • Mina Ghoreyshi, Maryam Mahmoudabady, Soleyman Bafadam, and Saeed Niazmand, “The Protective Effects of Pharmacologic Postconditioning of Hydroalcoholic Extract of Nigella sativa on Functional Activities and Oxidative Stress Injury During Ischemia–Reperfusion in Isolated Rat Heart,” Cardiovascular Toxicology, 2019. View at Publisher · View at Google Scholar
  • Maryam Mahmoudabady, Mohmmad Soukhtanloo, Parichehr Hayatdavoudi, Abbasali Abbasnezhad, Saeed Niazmand, Seyed Abdolrahim Rezaee, and Razieh Mosallanejad, “Nigella sativa L. seed regulated eNOS, VCAM-1 and LOX-1 genes expression and improved vasoreactivity in aorta of diabetic rat,” Journal of Ethnopharmacology, vol. 228, pp. 142–147, 2019. View at Publisher · View at Google Scholar