Evaluation of Bax and Bak Gene Mutations and Expression in Breast Cancer

Table 3

Chi-square test was done for the distribution of the Bax G-248A SNP.

Factors		G→G			G→A			A→A			G→A + A→A			𝑃^1	𝑃^3
Number^a		Number	%	𝑃	Number	%	𝑃	Number	%	𝑃	Number	%	𝑃^2
Normal	18	5	27.8	0.9	11	61.1	0.6	3	16.7	0.4	14	77.8	0.9	0.011	0.003
Tumor	19	5	26.3		10	5.26		5	26.3		15	78.9		0.15	0.001
Grade
2	17	7	41.2	0.16	10	58.8	0.7	5	29.4	0.4	15	88.2	0.4	0.2	0.004
3+ high	4	0	0		2	50.0		2	50		4	100		0.002	0.002
T stage
T1	3	1	33.1	0.3	0	0	0.1	2	66.7	0.6	2	66.7	0.3	0.2	0.4
T2	8	1	12.5		6	75.0		1	12.5		7	87.5		0.009	0.03
T3	4	2	50		2	50		0	0		2	50.0		0.1	0.1
T4	7	2	28.6		3	42.9		2	28.6		5	71.4		0.8	0.1
L.N.
N0	7	0	0	0.3	4	57.1	0.8	3	42.9	0.4	7	100	0.04	0.2	0.000
N1	6	4	66.7		2	33.3		0	0		2	33.3		0.2	1.2
N3 + N2	9	2	22.2		4	44.4		2	22.2		6	66.7		0.4	0.06
Histopathology
Duct	19	6	31.6	0.3	7	36.8	0.04	5	26.3	0.3	12	63.2	0.2	0.3	0.7
Lab + other	3	—	0		3	100		0	0		3	100		0.01	0.01
ER
Positive	11	3	27.3	0.6	5	45.5	0.4	3	27.3	0.6	8	72.7	0.6	0.5	0.003
Negative	6	1	16.7		4	66.7		1	16.7		5	83.3		0.1	0.2
PR
Positive	9	2	22.2	0.7	4	44.4	0.2	3	33.3	0.38	7	77.8	0.7	0.6	0.02
Negative	7	1	14.3		5	71.4		1	14.3		6	85.7		0.03	0.008

aSome cases are omitted because of missing values.
𝑃: chi-square test was used to determine the statistical significant distribution of each genotype between the subgroups. Statistical significance was at 𝑃≤0.05.
𝑃¹: chi-square test was used to determine the statistical significant distribution of the three genotypes in each subgroups. Statistical significance was at 𝑃≤0.05.
𝑃²: the significant distribution of the combined variant (i.e., G-A + A-A) among each group by chi-square test. Statistical significance was at 𝑃≤0.05.
𝑃³: the significant distribution of the wild type genotype and the combined variant (i.e., G-A + A-A) in each subgroup by chi-square test. Statistical significance was at 𝑃≤0.05.