Synchronous and Metachronous Breast Malignancies: A Cross-Sectional Retrospective Study and Review of the Literature

Table 5

Characteristics of second MBC stratified per time interval after diagnosis of first MBC. We considered as cutoff the median time interval that was 47 months. In this table we present mean values (±standard deviation) and one way ANOVA^∗ or prevalences and chi-square test.

	≤47 moths	>47 months	𝑃
Women age (years)^∗	63.14 (±14.22)	54.67 (±13.47)	<0.05
BMI (kg/m^2)^∗	25.2 (±4.01)	26.6 (±7.08)	0.448
Multifocality	28.57% (6/21)	26.32% (5/19)	0.873
Extended in situ component	42.86% (9/21)	21.05% (4/19)	0.141
Peritumoral vascular invasion	9.52% (2/21)	5.26% (1/19)	0.609
ER positivity	57.14% (12/21)	78.95% (15/19)	0.141
PR positivity	42.86% (9/21)	78.95% (15/19)	<0.05
HER-2/Neu positivity	14.29% (3/21)	10.53% (2/19)	0.720
Histology
Ductal invasive carcinoma	61.9% (13/21)	68.42% (13/19)	0.666
Lobular invasive carcinoma	23.81% (5/21)	0% (0/19)	<0.05
Ductal and lobular invasive carcinoma	4.76% (1/21)	5.26% (1/19)	0.942
Ductal in situ carcinoma	9.52% (2/21)	26.32% (5/19)	0.163
Grading
G1	14.29% (3/21)	0% (0/19)	0.087
G2	47.62% (10/21)	63.16% (12/19)	0.324
G3	38.1% (8/21)	36.84% (7/19)	0.935
Mib-1/Ki-67 (%)
1 to 20	43.75% (7/16)	11.11% (1/9)	0.093
20 to 30	12.5% (2/16)	11.11% (1/9)	0.918
>30	43.75% (7/16)	77.78% (7/9)	0.100