A Knowledge-Driven Approach to Extract Disease-Related Biomarkers from the Literature
Table 2
Examples of sentences including disease-biomarker cooccurrences.
Disease (CUI)a
Biomarker (Gene ID)b
PMID (year)
Sentence
Hodgkin’s lymphoma (C0019829)
Anti-Mullerian hormone (268)
17726078 (2007)
Anti-Mullerian hormone is a sensitive serum marker for gonadal function in women treated for Hodgkin’s lymphoma during childhood. (TITLE)
TCC (C1861305)
CK20 (54474)
17397492 (2007)
CK20 is an important biomarker that can be used to identify TCC in urine cytology smears. (CONCLUSIONS)
Autism (C0004352)
Brain-derived neurotrophic factor (BDNF) (627)
19119429 (2008)
To investigate levels of brain-derived neurotrophic factor (BDNF) in midpregnancy and neonatal blood specimens as early biologic markers for autism; we conducted a population-based case-control study nested within the cohort of infants born from July 2000 to September 2001 to women who participated in the prenatal screening program in Orange County, CA. (BODY)
Neutrophil gelatinase-associated lipocalin (NGAL) and netrin-1 have been proposed over the past years as emergent biomarkers for the early and accurate diagnosis and monitoring of acute kidney injury (AKI). (BODY)
Chronic heart failure (C0264716)
Cardiac troponin I (7137)
21751783 (2011)
Top-down quantitative proteomics identified phosphorylation of cardiac troponin I as a candidate biomarker for chronic heart failure. (TITLE)
Adenocarcinomas (C0001418)
MOC-31 (4072)
21732548 (2011)
MOC-31 is an established immunologic marker to detect adenocarcinomas. (BODY)
Lung adenocarcinoma (C0152013)
ROM (6094)
21748260 (2012)
Hence, serum ROM level may be a useful biomarker for staging of lung adenocarcinoma. (BODY)
Concept unique identifier at UMLS. NCBI gene identifier.
