BioMed Research International / 2014 / Article / Tab 2

Research Article

A Knowledge-Driven Approach to Extract Disease-Related Biomarkers from the Literature

Table 2

Examples of sentences including disease-biomarker cooccurrences.

Disease (CUI)aBiomarker (Gene ID)bPMID

Hodgkin’s lymphoma (C0019829)Anti-Mullerian hormone
Anti-Mullerian hormone is a sensitive serum marker for gonadal function in women treated for Hodgkin’s lymphoma during childhood. (TITLE)
TCC (C1861305)CK20 (54474)17397492 (2007)CK20 is an important biomarker that can be used to identify TCC in urine cytology smears. (CONCLUSIONS)
Autism (C0004352)Brain-derived neurotrophic factor (BDNF) (627)19119429
To investigate levels of brain-derived neurotrophic factor (BDNF) in midpregnancy and neonatal blood specimens as early biologic markers for autism; we conducted a population-based case-control study nested within the cohort of infants born from July 2000 to September 2001 to women who participated in the prenatal screening program in Orange County, CA. (BODY)
Acute kidney injury (AKI) (C0022660) Neutrophil gelatinase-associated lipocalin (NGAL) (3934), netrin-1 (9423)21740336
Neutrophil gelatinase-associated lipocalin (NGAL) and netrin-1 have been proposed over the past years as emergent biomarkers for the early and accurate diagnosis and monitoring of acute kidney injury (AKI). (BODY)
Chronic heart failure (C0264716)Cardiac troponin I (7137)21751783
Top-down quantitative proteomics identified phosphorylation of cardiac troponin I as a candidate biomarker for chronic heart failure. (TITLE)
Adenocarcinomas (C0001418)MOC-31 (4072)21732548
MOC-31 is an established immunologic marker to detect adenocarcinomas. (BODY)
Lung adenocarcinoma (C0152013)ROM (6094)21748260
Hence, serum ROM level may be a useful biomarker for staging of lung adenocarcinoma. (BODY)

Concept unique identifier at UMLS.
NCBI gene identifier.