Research Article
Usefulness of Anticoagulant Therapy in the Prevention of Embolic Complications in Patients with Acute Infective Endocarditis
Table 2
Characteristics of patients with and without ACT at admission:
(%).
| | | ACT (−)
| ACT (+)
| value |
| | Age ≥ 65 | 15 (15.2) | 14 (27.5) | 0.071 | | Male | 68 (68.7) | 33 (64.7) | 0.622 | | Hypertension | 20 (20.2) | 6 (11.8) | 0.196 | | Diabetes mellitus | 18 (18.2) | 10 (19.6) | 0.832 | | Atrial fibrillation | 12 (12.1) | 31 (60.8) | <0.001 | | Smoking | 14 (14.1) | 7 (13.7) | 0.945 | | History of IE | 1 (1.0) | 1 (2.0) | 1.000 | | Dialysis | 0 (0.0) | 2 (3.9) | 0.114 | | History of CHF | 15 (15.2) | 28 (54.9) | <0.001 | | Comorbidity index > 2 | 17 (17.2) | 15 (29.4) | 0.083 | | Prosthetic valve | 15 (15.2) | 49 (96.1) | <0.001 | | Mitral valve IE | 77 (77.8) | 36 (70.6) | 0.333 | | Aortic valve IE | 46 (46.5) | 26 (51.0) | 0.600 | | Dual valve IE | 24 (24.2) | 10 (19.6) | 0.521 | | Staphylococcus aureus | 12 (12.1) | 8 (15.7) | 0.543 | | CRP mg/dL | | | 0.393 | | Diagnostic delay, days | | | <0.001 | | Echocardiographic findings | | | | | Vegetation > 1 cm | 58 (58.6) | 14 (27.5) | <0.001 | | Mobile vegetation | 56 (56.6) | 20 (39.2) | 0.044 | | Paravalvular infection | 28 (28.3) | 12 (23.5) | 0.533 | | IE-related valve regurgitation | 91 (91.9) | 30 (58.8) | <0.001 | | At admission | | | | | Any embolism | 33 (33.3) | 10 (19.6) | 0.078 | | Any cerebrovascular event | 21 (21.2) | 9 (17.6) | 0.605 | | Brain infarct | 20 (20.2) | 8 (15.7) | 0.501 | | Intracranial hemorrhage | 4 (4.0) | 5 (9.8) | 0.274 | | During the entire disease period | | | | | Any embolism | 43 (43.4) | 14 (27.5) | 0.056 | | Any cerebrovascular event | 30 (30.3) | 15 (29.4) | 0.910 | | In-hospital mortality | 16 (16.2) | 13 (25.5) | 0.171 |
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ACT: anticoagulant therapy; IE: infective endocarditis; CHF: congestive heart failure; CRP: C-reactive protein.
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