Research Article

Pu-Erh Tea Extract Induces the Degradation of FET Family Proteins Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis

Figure 7

Reduction in FUS-positive cytoplasmic granules by PTE under stress conditions. (a) SK-N-SH cells stably expressing R521C FUS/TLS were treated with or without PTE (200 μg/mL) for 24 h. (b) SK-N-SH cells stably expressing R521C FUS/TLS were treated with or without PTE (200 μg/mL) for 24 h, following treatment with 1 mM arsenite. Cells were subsequently fixed and analyzed by immunofluorescence microscopy using anti-V5 antibody and DAPI.
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254680.fig.007b
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