Influence of Egr-1 in Cardiac Tissue-Derived Mesenchymal Stem Cells in Response to Glucose Variations

Figure 4

Gene expression profile of cMSCs after in vitro glucose conditioning. (a) Egr-1 mRNA levels in wt cMSCs are significantly increased in absence of glucose and compared to the 50 mM condition. A similar fashion can be observed as well with regard to (b) p300, (c) GLUT-1, and (d) GLUT-4. Differently, the same mRNA gene levels are significantly downregulated or unaffected in Egr-1^−/− cMSCs compared to the basal condition. The 25 mM condition was considered as reference. ^∗𝑃<0.05. ^∗∗𝑃<0.01.

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