Influence of Egr-1 in Cardiac Tissue-Derived Mesenchymal Stem Cells in Response to Glucose Variations
Figure 5
(a) The absence of glucose in wt cMSCs is able to induce a striking upregulation of TGFβ-1, whose mRNA levels significantly decrease at 50 mM glucose. In Egr-1−/− cMSCs mRNA levels are significantly downregulated compared to the basal condition both in absence and at 50 mM of glucose. (b) VEGF mRNA levels are significantly increased at the highest concentration of glucose in wt cMSCs, which is also statistically significantly increased compared to the absence of glucose, whereas in absence of Egr-1 gene this fluctuation is abolished. The 25 mM condition was considered as reference. . .
