Manufacturing Economics of Plant-Made Biologics: Case Studies in Therapeutic and Industrial Enzymes

Table 2

Capital cost factors for rBuChE case study.

Capital cost factors
Estimated based on PC (listed equipment PC plus unlisted equipment PC)
Unlisted equipment	0.2 listed purchased equipment cost
Direct costs	Plant growth		Agroproduction/infiltration		rBuChE recovery/purification
Piping	0.1	PC	0.35	PC	0.35	PC
Instrumentation	0.2	PC	0.4	PC	0.4	PC
Insulation	0.01	PC	0.03	PC	0.03	PC
Electrical facilities	0.1	PC	0.1	PC	0.1	PC
Building	0.2	PC	0.45	PC	3	PC
Yard improvement	0.15	PC	0.15	PC	0.15	PC
Auxiliary facilities	0.1	PC	0.4	PC	0.4	PC
UE installation	0.5	UEPC	0.5	UEPC	0.5	UEPC
Direct costs multiplicative factor	2.35		2.88		5.43
Engineering	0.25	DC	0.25	DC	0.25	DC
Construction	0.35	DC	0.35	DC	0.35	DC
Indirect costs multiplicative factor	1.41		1.73		3.26
Contractors fee	0.05	DC + IC	0.05	DC + IC	0.05	DC + IC
Contingency	0.1	DC + IC	0.1	DC + IC	0.1	DC + IC
Other costs multiplicative factors for DFC	0.56		0.69		1.30
Total multiplicative factor for DFC	4.33		5.30		9.99
Total multiplicative factor for TCI (except working capital)	4.54		5.56		10.49

PC: purchase cost; DC: direct cost; IC: indirect cost; UEPC: unlisted equipment purchase cost; DFC: direct fixed capital; TCI: total capital investment.