Research Article
Mutation Status and Immunoglobulin Gene Rearrangements in Patients from Northwest and Central Region of Spain with Chronic Lymphocytic Leukemia
Table 1
Mutation status (≥98% homology) and its relationship with IGHV rearrangements and sex.
| IGHV family | Mutated cases | Unmutated cases | Mutated and unmutated | % | | Male/female |
| IGHV1 | 2 | 5 | 7 | 3.2 | ns | 4/3 | IGHV1-02 | 3 | 7 | 10 | 4.6 | ns | 5/5 | IGHV1-03 | 2 | 2 | 4 | 1.9 | ns | 0/4 | IGHV1-08 | 3 | 2 | 5 | 2.3 | ns | 3/2 | IGHV1-18 | 2 | 2 | 4 | 1.9 | ns | 4/0 | IGHV1-46 | 3 | 1 | 4 | 1.9 | ns | 3/1 | IGHV1-69 | 3 | 18 | 21 | 9.7 | <0.0001 | 15/6 | Total IGHV1 | 18 | 37 | 55 | 25.5 | <0.0001 | 34/21 | IGHV2-01 | 1 | 0 | 1 | 0.5 | ns | 0/1 | IGHV2-05 | 0 | 1 | 1 | 0.5 | ns | 0/1 | IGHV2-70 | 0 | 1 | 1 | 0.5 | ns | 1/0 | Total IGHV2 | 1 | 2 | 3 | 1.4 | ns | 1/2 | IGHV3 | 3 | 2 | 5 | 2.3 | ns | 3/2 | IGHV3-07 | 8 | 1 | 9 | 4.0 | ns | 9/0 | IGHV3-09 | 2 | 2 | 4 | 1.9 | ns | 2/2 | IGHV3-11 | 0 | 5 | 5 | 2.3 | 0.016 | 4/1 | IGHV3-13 | 1 | 2 | 3 | 1.4 | ns | 3/0 | IGHV3-15 | 4 | 2 | 6 | 2.8 | ns | 2/4 | IGHV3-20 | 1 | 1 | 2 | 0.9 | ns | 1/1 | IGHV3-21 | 6 | 1 | 7 | 3.2 | ns | 5/2 | IGHV3-23 | 18 | 1 | 19 | 8.8 | <0.0001 | 12/7 | IGHV3-30 | 12 | 10 | 22 | 10.0 | ns | 17/5 | IGHV3-33 | 4 | 3 | 7 | 3.2 | ns | 5/2 | IGHV3-48 | 1 | 2 | 3 | 1.4 | ns | 3/0 | IGHV3-49 | 2 | 2 | 4 | 1.9 | ns | 1/3 | IGHV3-53 | 1 | 0 | 1 | 0.5 | ns | 1/0 | IGHV3-64 | 0 | 1 | 1 | 0.5 | ns | 1/0 | IGHV3-72 | 2 | 0 | 2 | 0.9 | ns | 2/0 | IGHV3-74 | 7 | 0 | 7 | 3.2 | 0.018 | 5/2 | Total IGHV3 | 72 | 35 | 107 | 49.5 | 0.004 | 85/22, | IGHV4-b | 2 | 2 | 4 | 1.9 | ns | 1/3 | IGHV4-04 | 5 | 0 | 5 | 2.3 | 0.051 | 3/2 | IGHV4-30 | 1 | 1 | 2 | 0.9 | ns | 1/1 | IGHV4-31 | 0 | 1 | 1 | 0.5 | ns | 1/0 | IGHV4-34 | 14 | 4 | 18 | 8.3 | ns | 11/7 | IGHV4-39 | 3 | 3 | 6 | 2.8 | ns | 3/3 | IGHV4-59 | 2 | 0 | 2 | 0.9 | ns | 1/1 | IGHV4-61 | 3 | 0 | 3 | 1.4 | ns | 2/1 | Total IGHV4 | 30 | 11 | 41 | 19 | 0.022 | 23/18 | IGHV5-05 | 0 | 1 | 1 | 0.5 | ns | 1/0 | IGHV5-51 | 1 | 6 | 7 | 3.2 | 0.046 | 7/0 | Total IGHV5 | 1 | 7 | 8 | 3.7 | 0.023 | 8/0, | IGHV7-04 | 0 | 2 | 2 | 0.9 | ns | 0/2 | Total IGHV7 | 0 | 2 | 2 | 0.9 | ns | 0/2 |
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