Figure 3: The expanded addictive drug-target network after filtering by hubs and bridge nodes. The red nodes denote addictive drugs, the green nodes denote targets, the yellow nodes denote nonaddictive drugs that have a significantly higher cooccurrence than expected with addiction-related keywords in the literature from PubMed, and the blue nodes denote non-addictive drugs that have a co-occurrence with addiction keywords but are not significantly higher than expected in the literature data.