Review Article
New Insights into Monoclonal B-Cell Lymphocytosis
Table 3
Main clinical, cytogenetic, and molecular features of CLL-0, CLL>0, HC-MBL, and LC-MBL.
| | Characteristics | CLL>0 | CLL-0 | HC-MBL | LC-MBL | | % |
| | Annual risk of progression | | 5.2 | 1.1 | 0 | | Del 13q | 50 | ~40 | ~40 | ~30 | | Trisomy 12 | 16 | ~20 | ~20 | ~10 | | Del 11q | 18 | ~5 | ~5 | 0 | | Del 17p | 7 | 2-3 | 0–3 | 0 | | Unmutated IGHV genes | ~45 | ~25 | ~25 | ~25 | | VH1-69 | ~13 | ~5 | ~8 | ~3 | | VH4-59/61 | <5 | ~5 | <5 | ~20 | | BCR stereotypy | ~5 | ~20 | ~20 | ~30 | | NOTCH 1 mutation | >15 | 13 | 11 | 0 |
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