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Study | Animal species | Injury model | Main experimental groups | Method/dose of statin administration | Anesthetic agent | Time of statin administration | Time of outcome measurement | Quality score |
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Abrahamson et al., 2009 [24] | Male mice | CCI | (1) TBI + vehicle ( = 5-6) (2) TBI + simvastatin ( = 5-6) | Orally, 3 mg/kg/d | Isoflurane | 3 h after injury | 10–14 d after injury | 5 |
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Chauhan and Gatto, 2011 [16] | Male C57BL/6J mice | CCI | (1) TBI+ saline () (2) TBI + pravastatin () (3) TBI + lovastatin () (4) TBI + simvastatin () | Orally, 2 mg/kg/d for 8 weeks | Ketamine | immediately after injury | 7-8 weeks after injury | 3 |
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Indraswari et al., 2012 [25] | Male C57BL/6J mice | CCI | (1) TBI + saline () (2) TBI + rosuvastatin () | Orally, 1 mg/kg/d for 5 d | Isoflurane | within 1 h after injury | 31–34 d after injury | 8 |
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Lu et al., 2004 [26] | Male Wistar rats | CCI | (1) TBI + saline () (2) TBI + atorvastatin () | Orally, 1 mg/kg/d for 7 d | Chloral hydrate | 1 d after injury | 1, 4, 8, and 15 d after injury | 7 |
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Lu et al., 2007 [13] | Male Wistar rats | CCI | (1) TBI + saline () (2) TBI + atorvastatin () and (1) TBI + saline () (2) TBI + atorvastatin () (3) TBI + simvastatin () | orally 1 mg/kg/d for 14 d | Chloral hydrate | 1 d after injury | 11–15 and 31–35 d after injury | 7 |
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Wang et al., 2012 [27] | Male Wistar rats | FPI | (1) TBI + control () (2) TBI + atorvastatin () | Orally, 1 mg/kg/d for 14 d | Chloral hydrate | 1 h after injury | 21–25 d after injury | 5 |
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Wang et al., 2007 [28] | Male C57Bl/6J mice | CHI | (1) TBI + vehicle ( = ?) (2) TBI + simvastatin ( = ?) (3) TBI + atorvastatin ( = ?) | Subcutaneous injection, 20 mg/kg/d for 17 d | Isoflurane | Unclear | 21–25 d after injury | 4 |
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Wu et al., 2008 [10] | Male Wistar rats | CCI | (1) TBI + saline () (2) TBI + simvastatin () | Orally, 1 mg/kg/d for 14 d | Chloral hydrate | 1 d after injury | 31–35 d after injury | 7 |
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Jin et al., 2013 [29] | Male Wistar rats | FPI | (1) TBI + saline () (2) TBI + atorvastatin () | Orally, 1 mg/kg/d for 14 d | Chloral hydrate | Within 1 h after injury | 21–25 d after injury | 4 |
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Liu, 2009 [30] | Male Wistar rats | FPI | (1) TBI + saline () (2) TBI + simvastatin () | Orally, 20 mg/kg/d, unclear treatment duration | Chloral hydrate | 1 d after injury | 21–25 d after injury | 5 |
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Zhang et al., 2012 [31] | Male Wistar rats | FPI | (1) TBI + saline () (2) TBI + atorvastatin () (3) TBI + simvastatin () (4) TBI + rosuvastatin () | Orally, atorvastatin/simvastatin: 2 mg/kg/d for 21 d, rosuvastatin: 1 mg/kg/d for 21 d | Chloral hydrate | Within 1 d after injury | 22–28 d after injury | 5 |
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