Impact of Statins on Cognitive Deficits in Adult Male Rodents after Traumatic Brain Injury: A Systematic Review

Table 5

Metaregression analysis to identify sources of bias associated with study characteristics.

(a) Acquisition memory

Covariates	Coef.	Std. err.	𝑡	𝑃>|𝑡|	[95% conf. interval]
Species	−1.218926	1.425615	−0.86	0.415	−4.443892	2.00604
Quality	−.1059611	.5134567	−0.21	0.841	−1.267481	1.055559
Route	1.794537	2.46653	0.73	0.485	−3.785142	7.374215
Statins
Atorva	−4.098033	2.606752	−1.57	0.167	−10.47653	2.28046
Lova	.1509175	3.110633	0.05	0.963	−7.460527	7.762362
Prava	−1.058402	2.688579	−0.39	0.707	−7.637118	5.520313
Simva	−1.752053	2.462111	−0.71	0.503	−7.776621	4.272516
Dose
1 mg	−2.813334	2.734279	−1.03	0.338	−9.278877	3.652209
2 mg	−.0024291	2.536972	−0.00	0.999	−6.001415	5.996557
20 mg	−1.646112	2.854527	−0.58	0.582	−8.395994	5.103771
Anaesthetic used
Chloral hydrate	−.3426693	2.006333	−0.17	0.869	−4.969281	4.283942
Ketamine	1.502998	2.222102	0.68	0.518	−3.621178	6.627174
Injury model
CCI	2.776583	2.521451	1.10	0.303	−3.037893	8.591059
FPI	1.121622	2.456371	0.46	0.660	−4.54278	6.786024

(b) Retention memory

Covariates	Coef.	Std. err.	𝑡	𝑃>|𝑡|	[95% conf. interval]
Species	−2.045101	.7652448	−2.67	0.023	−3.750172	−.3400288
Dose	−1.358647	.8065987	−1.68	0.123	−3.155861	.4385665
Quality	.5416233	.2248974	2.41	0.037	.0405206	1.042726
Anaesthetic used	2.045101	.7652448	2.67	0.023	.3400288	3.750172
Injury model	−.5074523	.9452993	−0.54	0.603	−2.61371	1.598806
Statins
Atorva	.4747928	1.355065	0.35	0.736	−2.729427	3.679012
Lova	−.4478023	1.743837	−0.26	0.805	−4.571322	3.675718
Prava	−2.709569	1.71473	−1.58	0.158	−6.764262	1.345123
Simva	.9555847	1.387517	0.69	0.513	−2.325371	4.23654