Research Article
Nutritional Biomarkers in Children and Adolescents with Beta-Thalassemia-Major: An Egyptian Center Experience
Table 1
Demographic, clinical, and laboratory data of patients and controls.
| | Parameter | Patients | Controls | |
| | Age (years); mean ± SD (range) | (2–17) | (4–17) | 0.59 | | Sex; (%) | | | 0.68 | | Male | 68 (63) | 36 (60) | | | Female | 40 (37) | 24 (40) | | | Height in cm; mean ± SD | | | 0.04* | | Weight in kg; mean ± SD | | | 0.01* | | Positive consanguinity; (%) | 67 (62.05) | — | — | | Similar condition in the family; (%) | 43 (39.8) | — | — | | Packed RBCs transfusion index (mL/kg/year) | | — | — | | Splenectomy, (%) | 31 (29.6) | — | — | | Hypovitaminosis: (%) | | | | | Xerodrema with scaling | 37 (34.3) | — | — | | Neuropsychiatric manifestations | 43 (39.8) | — | | | Chelation therapy: (%) | | — | — | | Deferiprone | 36 (33.3) | | | | Deferoxamine | 27 (25) | | | | Both | 45 (41.7) | | | | Compliance to chelation therapy, (%) | 47 (43.5) | — | — | | WBCs (103/uL); mean ± SD (range) | (4.7–20.5) | (4–11.7) | 0.08 | | HB (g/dL) | | | 0.001* | | PLT (103/uL) | | | 0.94 | | Total bilirubin (mg/dL) | | | 0.02* | | AST (U/L) | | | 0.02* | | ALT (U/L) | | | 0.04* | | Creatinine (mg/dL) | | | 0.61 | | Ferritin (ng/mL) | | | 0.001* |
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: number; *significant statistically; RBCs: red blood cells; WBCs: white blood cells; HB: hemoglobin; PLT: platelets; AST: aspartate transaminase; ALT: alanine transaminase.
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