Recognition of 27-Class Protein Folds by Adding the Interaction of Segments and Motif Information

Table 1

Datasets of 27-class protein folds.

Fold	Dataset built by Liu et al. [27]		Dataset built by Ding and Dubchak [11]
	Training set	Testing set	Training set	Testing set
All 𝛼 structural class	174	169	54	61
(1) Globin-like	14	14	13	6
(2) Cytochrome c	10	10	7	9
(3) DNA-binding 3-helical bundle	92	90	12	20
(4) 4-helical up-and-down bundle	25	24	7	8
(5) 4-helical cytokines	8	8	9	9
(6) Alpha; EF-hand	25	23	6	9
All β structural classes	260	254	109	117
(7) Immunoglobulin-like β-sandwich	86	85	30	44
(8) Cupredoxins	18	18	9	12
(9) Viral coat and capsid proteins	24	24	16	13
(10) ConA-like lectins/glucanases	18	17	7	6
(11) SH3-like barrel	41	41	8	8
(12) OB-fold	29	28	13	19
(13) Trefoil	11	10	8	4
(14) Trypsin-like serine proteases	17	16	9	4
(15) Lipocalins	16	15	9	7
𝛼/β structural class	341	337	115	143
(16) (TIM)-barrel	93	92	29	48
(17) FAD (also NAD)-binding motif	5	5	11	12
(18) Flavodoxin-like	37	36	11	13
(19) NAD(P)-binding Rossmann-fold	17	16	13	27
(20) P-loop-containing nucleotide	74	73	10	12
(21) Thioredoxin-like	37	36	9	8
(22) Ribonuclease H-like motif	39	40	10	12
(23) Hydrolases	33	33	11	7
(24) Periplasmic binding protein-like	6	6	11	4
𝛼 + β structural class	181	179	33	62
(25) β-Grasp	39	39	7	8
(26) Ferredoxin-like	101	99	13	27
(27) Small inhibitors, toxins, and lectins	41	41	13	27
Overall	956	939	311	383