β-Thalassemia Intermedia in Northern Iraq: A Single Center Experience

Table 2

The 𝛽-and 𝛼-genotypes and Xmn I polymorphism status in the 51 families enrolled in the current study.

𝛽-Genotype	Xmn I	Alpha genotype	Number
𝛽^+/𝛽^+
IVS-1-6 (T>C)/IVS-I-6 (T>C)	−/−	α α/α α	12
IVS-I-128 (T>G)/IVS-I-128 (T>G)	−/−	α α/α α	1
−28 (A>C)/−28 (A>C)	−/−	α α/α α	1
IVS-I-6 (T>C)/−30 (T>A)	−/−	α α/α α	1
𝛽^+/𝛽^0
IVS-I-6 (T>C)/IVS-II-1 (G>A)	+/−	α α/α α	2
IVS-I-6 (T>C)/Codon 8 (−AA)	+/−	α α/α α	2
Poly A (AATAAA>AATAAG)/Codon 5 (−CT)	+/−	α α/α α	2
IVS-I-6 (T>C)/Codon 5 (−CT)	−/−	α α/α α	1
IVS-I-6 (T>C)/Codon 39 (C>T)	−/−	α α/α α	1
IVS-I-6 (T>C)/Codon 82/83 (−G)	+/−	α α/α α	1
IVS-I-6 (T>C)/IVS-I-1 (G>A)	−/−	α α/α α	1
Poly A (AATAAA>AATAAG)/IVS-1-130 (G>C)	−/−	α α/α α	1
IVS-II-1 (G>A)/IVS-I-110 (G>A)	+/−	α α/α α	1
Codon 8 (−AA)/IVS-I-110 (G>A)	+/−	−𝛼^3.7/α α	1
𝛽^0/𝛽^0
IVS-II-I (G>A)/IVS-II-1 (G>A)	+/+	α α/α α	4
Codon 82/83 (−G)/Codon 82/83 (−G)	+/+	α α/α α	4
Codon 82/83 (−G)/IVS-II-1 (G>A)	+/+	α α/α α	1
Codon 8 (−AA)/Codon 8 (−AA)	+/+	α α/α α	1
Codon 8 (−AA)/IVS-II-1 (G>A)	+/+	α α/α α	1
Codon 8 (−AA)/IVS-II-1 (G>A)	+/−	α α/α α	1
Codon 8 (−AA)/IVS-I-1 (G>A)	+/−	α α/α α	1
IVS-II-1 (G>A)/Codon 44 (−C)	+/−	α α/α α	1
IVS-II-1 (G>A)/IVS-I-1 (G>A)	+/−	α α/α α	1
IVS-II-1 (G>A)/IVS-I-130 (G>C)	+/−	α α/α α	1
IVS-II-1 (G>A)/IVS-II-1 (G>A)	+/−	−𝛼^3.7/α α	1
IVS-II-1 (G>A)/Codon 44 (−C)	+/−	−𝛼^3.7/α α	1
IVS-II-1 (G>A)/IVS-I-1 (G>A)	+/−	−𝛼^3.7/α α	1
IVS-I-130 (G>C)/Codon 5 (−CT)	−/−	α α/α α	1
𝛽^0/wild
Codon 5 (−CT)/wild	−/−	α αα/α α	1
Codon 5 (−CT)/wild	−/−	α α/α α	1
Codon 39 (C>T)/wild	−/−	α α/α α	1