Protective Role of 5-Lipoxigenase during Leishmania infantum Infection Is Associated with Th17 Subset
Figure 1
5-LO activity participates in the control of L. infantum infection. In (a), the WT BMDCs (1 × 106 cells/mL) were infected with L. infantum (1 : 5) (hatched bar) or medium (white bar) for 12, 24, 36, and 48 h and the LTB4 amount in the supernatant was determined by ELISA assay. The parasite burden in the spleen (b) and liver (c) was determined in the WT (white bars) and (black bars) mice at the 4th and 6th wpi with L. infantum promastigote forms ( parasites/mice-i.v. route). The data are expressed as the mean ± SEM, N = 5-6. compared with the WT group.
