Protective Role of 5-Lipoxigenase during Leishmania infantum Infection Is Associated with Th17 Subset
Figure 3
5-LO ablation decreased the Th17, but not the Th1, pattern of immune response. The spleen cells from the WT (white bars) or (black bars) mice at the 6th wpi were in vitro restimulated with PMA and ionomycin for 4 h and analyzed for intracellular cytokine production by flow cytometry. The dot plots represent the frequency of the CD4+ T cell-producing IFN- (a) and the CD4+ T cell-producing IL-17 (b), and the graph bars represent the percentage and the total number of these cells. The data are expressed as the mean ± SEM, N = 5-6. compared with the WT group.
