Evidence for Association of the E23K Variant of KCNJ11 Gene with Type 2 Diabetes in Tunisian Population: Population-Based Study and Meta-Analysis

Table 2

Genotypic and allelic distribution of the E23K variant in Tunisian patients with Type 2 diabetes and control subjects.

Genotype distribution

Allele

Allelic exact test

Global model

Additive model

Dominant model

Recessive model

T2DM patients (94 men/156 women)

Control subjects (105 men/162 women)

OR (95% CI)

𝑃

OR (95% CI)

𝑃

OR (95% CI)

𝑃

OR (95% CI)

𝑃

OR (95% CI)

𝑃

EE

142 (55/87) (56.8%)

173 (65/108) (64.79%)

0.063*

1.00

EK

89 (33/56) (35.6%)

86 (34/52) (32.21%)

0.416*

1.44 (0.94–2.2)

0.092

KK

19 (6/13) (7.6%)

8 (6/2) (3%)

0.019*

1.6 (1.14–2.27)

0.007

3.62 (1.26–10.41)

0.017

1.6 (1.07–2.41)

0.023

3.18 (1.11–9.07)

0.031

MAF (K)

0.254

0.19

1.44 (1.07–1.93)

0.015^†

0.017

𝑃 value for HWE

0.32

0.69

Genotype distributions are shown as number (%). MAF: minor allele frequency. ^∗𝑃 values comparing genotype distribution between patients with Type 2 diabetes and control subjects. ^†Allele-specific 𝑃 values. Odds ratio (OR), 95% CI, and 𝑃 values were from logistic regression analyses with additive, dominant, and recessive models controlling age, sex, and BMI as covariates. In additive models, ORs are expressed per difference in number of rare alleles.