Evidence for Association of the E23K Variant of KCNJ11 Gene with Type 2 Diabetes in Tunisian Population: Population-Based Study and Meta-Analysis

Table 3

Effects of KCNJ11 E23K variant on diabetes-related phenotypes.

Phenotype

T2DM group

ANOVA*

Control group

ANOVA*

T2DM and control subjects

ANOVA*

EE

EK

KK

𝑃 value

EE

EK

KK

𝑃 value

EE

EK

KK

𝑃 value

Fasting plasma glucose (mmol/L)

11.03±3.89

12.49±4.13

10.81±4.48

0.04

5.26±0.5

5.12±0.5

5.5±0.42

0.13

7.93±3.93

9.32±4.81

9.54±4.53

0.03^†

Mean BMI (kg/m^2)

29±5.48

28.84±5.82

28.55±4.48

0.94

28.24±5.61

28.33±4.5

27.17±4

0.89

28.61±5.55

28.63±5.29

28.24±4.32

0.95

Total cholesterol (mmol/L)

5.06±1.07

5.02±1.04

5.17±1.25

0.88

5.01±0.97

5.2±0.96

4.7±0.64

0.39

5.03±1.01

5.09±1

5.06±1.15

0.89

Triglycerides (mmol/L)

1.75±0.88

1.67±0.81

2.03±1.34

0.85^†

1.33±0.63

1.33±0.5

1.22±0.31

0.7^†

1.52±0.79

1.53±0.71

1.85±1.23

0.69^†

HDL-cholesterol (mmol/L)

1.23±0.42

1.21±0.44

1.27±0.29

0.95

1.49±0.4

1.39±0.4

1.26±0.4

0.23

1.42±0.42

1.33±0.42

1.27±0.32

0.26

Systolic blood pressure (mmHg)

14.49±2.13

14.45±1.97

14.37±2.02

0.98

13.34±2.14

13.47±2.45

15±1.41

0.34

13.92±2.21

14.06±2.22

14.5±1.88

0.52

Diastolic blood pressure (mmHg)

8.39±1.15

8.12±1.14

8.09±0.80

0.25

8.33±6.3

7.7±1.32

8±0.82

0.53^†

8.36±4.47

7.95±1.23

8.07±0.78

0.32^†

LDL-cholesterol (mmol/L)

3.01±1.05

2.5±0.61

2.65±0.39

0.10^†

2.90±0.91

3.18±0.87

2.94±0.64

0.20

2.93±0.95

2.97±0.84

2.78±0.50

0.83

Values are mean ± standard deviation. *ANOVA was used to compare geometric mean levels of continuous characteristics across genotypes. ^†P value of Kruskal-Wallis test for unequal variance.