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BioMed Research International
Volume 2014, Article ID 265435, 5 pages
http://dx.doi.org/10.1155/2014/265435
Research Article

The Effects of Gene Polymorphisms in Interleukin-4 and Interleukin-6 on the Susceptibility of Rheumatoid Arthritis in a Chinese Population

1Department of Orthopaedics, General Hospital of Chinese People’s Liberation Army, Fuxing Road No. 28, Haidian District, Beijing 100853, China
2Department of Orthopaedics, University of Chicago Hospital, Maryland Avenue, Chicago, ll 60673, USA
3Department of Stomatology, General Hospital of Chinese People’s Liberation Army, Fuxing Road No. 28, Haidian District, Beijing 100853, China

Received 1 November 2013; Revised 16 December 2013; Accepted 9 January 2014; Published 23 February 2014

Academic Editor: Wei Chiao Chang

Copyright © 2014 Xiang Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Interleukin-4 (IL-4) and interleukin-6 (IL-6) have been reported to associate with pathogenesis of rheumatoid arthritis (RA); however, the role of IL-4 and IL-6 genetic polymorphisms in RA remains unknown. Method. A total of 752 unrelated Chinese patients with RA and 798 healthy Chinese volunteers with no family histories of any autoimmune diseases were recruited. The promoter IL-4-590 C/T and IL-6-174 G/C polymorphisms were genotyped. Result. The genotype distributions and allele frequencies of IL-4-590 C/T and IL-6-174 G/C polymorphisms in RA patients were significantly different from healthy volunteers. Statistically significant differences were observed in genotypes for IL-4-590 and IL-6-174. The frequencies of both the T allele on the IL-4-590 and the C on the IL-6-174 were significantly increased in RA patients. Conclusion. The IL-4-590 and IL-6-174 promoter polymorphisms may be associated with increased risk of RA and could be used as genetic marker for assessing the susceptibility and severity of RA in Chinese.