Potential Role of A_2B Adenosine Receptors on Proliferation/Migration of Fetal Endothelium Derived from Preeclamptic Pregnancies

Figure 2

Cell proliferation and migration induced by A_2BAR. HUVECs were isolated from normal (white bars) and preeclamptic pregnancies (grey bars) and used for (a) analysis of cell proliferation by MTS assay in presence (+) or absence (−) of NECA (10 μM, 24 h) and/or MRS-1754 (5 nM, 24 h) or (b) cell migration as described in (a). ^∗𝑃<0.05 versus basal condition in normal pregnancy. ^†𝑃<0.05 versus basal condition in preeclampsia. ^‡𝑃<0.05 versus respective value in normal pregnancy. Values are mean ± SEM. Values in respective control column indicate 𝑛. All experiments were performed in duplicate.

(a)

(b)