Potential Role of A_2B Adenosine Receptors on Proliferation/Migration of Fetal Endothelium Derived from Preeclamptic Pregnancies

Figure 5

Effects of NOS inhibitor on NECA-mediated cell proliferation/migration. (a) Cell proliferation in presence (+) or absence (−) of NECA (10 μM) and/or L-NAME (100 μM) during 24 hours in normal (white bars) or preeclamptic pregnancies (grey bars). (b) Cell migration as in (a). ^∗𝑃<0.05 versus respective value in basal conditions. ^†𝑃<0.05 versus respective value in normal pregnancy. Values are expressed in fold of change considering respective basal condition (i.e., without any treatment) in normal or preeclamptic cells. Values in mean ± SEM. Values in respective control column indicate 𝑛. All experiments were performed in duplicate.

(a)

(b)