Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 278098, 8 pages
Research Article

Monte Carlo Simulation of Protein Adsorption on Energetically Heterogeneous Surfaces

Department of Chemical Engineering, Faculty of Engineering, Thammasat University, 99 Moo 18 Phaholyothin Road, Khlong-Luang, Pathum Thani 12120, Thailand

Received 26 February 2014; Accepted 19 June 2014; Published 16 July 2014

Academic Editor: Ali A. Khraibi

Copyright © 2014 Panu Danwanichakul. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The modified triangular-well potential model was applied to incorporate the effect of surface energy on the adsorption of particles or proteins on energetically heterogeneous surfaces. The method is convenient in simulating the adsorption on heterogeneous surface of which different region possesses different free energy. Spherical particles with attractive forces were added on the surface and underwent surface diffusion before they were quenched in place. It was seen that the ratio of surface energies of two regions had to be greater than 10 in order to simulate the adsorption in which the particles were selectively adsorbed on a favorable area. At a fixed ratio of surface energies, the obtained structures were similar. If the ratio was less than 10, the probability of adsorption on any site on the surface was not much different so the adsorption would be homogeneous adsorption. The method, thus, could be applied widely to simulate the adsorption of various conditions.