Integrated Analysis of Gene Network in Childhood Leukemia from Microarray and Pathway Databases
Figure 2
Gene set enrichment analysis delineates gene ontology (GO) that differentiates between B- and T-ALL with respect to biological processes. Gene set enrichment analysis (GSEA) comparing B-ALL (red) and T-ALL (blue) in ALL dataset, illustrating differentiation of gene ontology (biological processes) between two subgroups (5% FDR, ). Cytoscape and enrichment map were used for visualization of the GSEA results; only gene sets from MSigDB C5 (gene ontology) were used. Nodes represent enriched GO gene sets, whose size reflects the total number of genes in that gene set. Edge thickness (green line) represents the number of overlapping genes between gene sets calculated using Jaccard coefficient. Single nodes and 2-node interactions for both B- and T-ALL, a 5 node-interaction for B-ALL, and interaction between a large number of nodes for T-ALL are shown.
